摘要
目的:探讨综合性干预措施对采用利妥昔单抗治疗的自身免疫性脑炎患者的认知能力、不良情绪、生活质量及药品不良反应的影响。方法:回顾性选取2018年1月至2022年4月于该院进行诊治的自身免疫性脑炎患者94例,根据护理方法的不同分为综合干预组(47例)与常规干预组(47例)。常规干预组采用常规护理干预,综合干预组采用综合性护理干预。比较两组患者的药品不良反应发生率、生命体征、认知能力(包括智力、记忆力及脑损伤程度)、不良情绪[焦虑自评量表(SAS)评分、抑郁自评量表(SDS)评分]和生活质量[健康调查简表(SF-36)评分]。结果:综合干预组、常规干预组患者的药品不良反应发生率分别为2.13%(1/47)、14.89%(7/47),综合干预组明显低于常规干预组,差异有统计学意义(P<0.05)。干预后,两组患者的生命体征比较,差异无统计学意义(P>0.05);综合干预组患者的智力、记忆力评分高于常规干预组,脑损伤程度评分低于常规干预组,差异均有统计学意义(P<0.05);综合干预组患者的SAS评分、SDS评分明显低于常规干预组,差异均有统计学意义(P<0.05);综合干预组患者的生理机能、躯体疼痛和社会功能等各项生活质量评分以及总分均明显高于常规干预组,差异均有统计学意义(P<0.05)。结论:综合性干预措施能够明显减少采用利妥昔单抗治疗的自身免疫性脑炎患者的药品不良反应,改善患者的认知能力,减轻不良情绪,提高生活质量,具有较高的临床应用价值。
OBJECTIVE:To probe into the effects of comprehensive interventions on cognitive ability,negative emotions,quality of life and adverse drug reactions in patients with autoimmune encephalitis treated with rituximab.METHODS:A total of 94 patients with autoimmune encephalitis who were diagnosed and treated in the hospital from Jan.2018 to Apr.2022 were retrospectively selected to be divided into the comprehensive intervention group(n=47)and routine intervention group(n=47)via different nursing methods.The routine intervention group was given routine nursing intervention,while the comprehensive intervention group was given comprehensive nursing intervention.The incidence of adverse drug reactions,vital signs,cognitive ability(including intelligence,memory and degree of brain damage),negative emotions[self-rating anxiety scale(SAS)score,self-rating depression scale(SDS)score]and quality of life[SF-36 score]were compared between two groups.RESULTS:The incidence of adverse drug reactions in the comprehensive intervention group and the routine intervention group was respectively 2.13%(1/47)and 14.89%(7/47),the comprehensive intervention group was significantly lower than the routine intervention group,the difference was statistically significant(P<0.05).After intervention,there was no statistically significant difference in vital signs between two groups(P>0.05);the intelligence and memory scores of the comprehensive intervention group were higher than those of the routine intervention group,and the degree of brain damage score was lower than that of the routine intervention group,the differences were statistically significant(P<0.05);the SAS and SDS scores of the comprehensive intervention group were significantly lower than those of the routine intervention group,with statistically significant differences(P<0.05);the scores of physiological function,body pain and social function and the total score of quality of life in the comprehensive intervention group were significantly higher than those in the routine intervention
作者
王娟
WANG Juan(Dept.of Neurology,Beijing Tongren Hospital,Beijing 102600,China)
出处
《中国医院用药评价与分析》
2023年第5期580-583,587,共5页
Evaluation and Analysis of Drug-use in Hospitals of China
