摘要
目的研究宫颈癌前病变并发感染早期筛查中高危型HPV检测与宫颈液基细胞学(TCT)检查的应用。方法回顾性选取2021年6月—2022年6月本院宫颈病变筛查女性868例,对比HR-HPV检测、TCT检查、HR-HPV检测联合TCT检查与病理学检查结果,统计分析HR-HPV检测、TCT检查单独与联合检测的诊断效能,并统计分析不同病理学检查结果女性的HR-HPV检测和TCT检查结果。结果HR-HPV检测的灵敏度为82.93%(136/164),特异度为93.18%(656/704),准确性为91.24%(792/868),阳性预测值为73.91%(136/184)。TCT检查的灵敏度为63.41%(104/164),特异度为94.89%(668/704),准确性为88.94%(772/868),阳性预测值为74.29%(104/140)。HR-HPV检测联合TCT检查的灵敏度为91.46%(150/164),特异度为98.86%(696/704),准确性为97.47%(846/868),阳性预测值为94.94%(150/158)。HR-HPV检测、TCT检查联合检测的灵敏度、准确性,阳性预测值均高于单独检测(P<0.05),HR-HPV检测的灵敏度、准确性均高于TCT检查(P<0.05)。宫颈癌、CINⅡ、CINⅢ女性的HR-HPV检测阳性率均高于TCT检查(P<0.05)。结论宫颈癌前病变并发感染早期筛查中,与单独检测相比,高危型HPV检测与宫颈液基细胞学检查联合检测的应用价值较高。
ObjectiveThis paper aims to study the application of high-risk HPV detection and cervical liquid-based cytology examination in the early screening of cervical precancerous lesions complicated with infection.Methods From June 2021 to June 2022,868 women who underwent cervical lesions screening in our hospital were retrospectively selected.The results of HR-HPV test,TCT test,HR-HPV test combined with TCT test and pathological test were compared,and the diagnostic efficacies of HR-HPV test and TCT test alone and their combined test were statistically analyzed,and the results of HR-HPV test and TCT test in women with different pathological test results were statistically analyzed.Results The sensitivity of HR-HPV detection was 82.93%(136/164),the specificity was 93.18%(656/704),the accuracy was 91.24%(792/868),and the positive predictive value was 73.91%(136/184).The sensitivity of TCT examination was 63.41%(104/164),the specificity was 94.89%(668/704),the accuracy was 88.94%(772/868),the positive predictive value was 74.29%(104/140).The sensitivity of HR-HPV detection combined with TCT test was 91.46%(150/164),the specificity was 98.86%(696/704),the accuracy was 97.47%(846/868),and the positive predictive value was 94.94%(150/158).The sensitivity,accuracy and positive predictive value of combined detection of HR-HPV detection and TCT test were higher than those of single detection(P<0.05),and the sensitivity and accuracy of HR-HPV detection were higher than TCT examination(P<O.05).The positive rates of HR-HPV detection in women with cervical cancer,CIN II and CINII were higher than those in TCT examination(P<0.05).Conclusion Compared with single detection,the application value of combined detection of high-risk HPV detection and cervical liquid-based cytology in early screening of cervical precancerous lesions complicated with infection is high.
作者
王典华
WANG Dian-hua(Xinxiang Maternal and Child Health Care Hospital,Henan 453003,China)
出处
《中国卫生检验杂志》
CAS
2023年第8期1002-1005,共4页
Chinese Journal of Health Laboratory Technology
关键词
宫颈癌前病变
感染
早期筛查
高危型HPV检测
宫颈液基细胞学检查
阴道镜下宫颈活检组织病理学检查
Cervical precancerous lesions
Infection
Early screening
High-risk HPV detection
Cervical liquid-based cytology
Colposcopy cervical biopsy histopathological examination
