摘要
目的:探讨宫腔镜治疗子宫瘢痕妊娠(CSP)后患者β-人绒毛膜促性腺激素(β-hCG)和炎性因子表达及其对疗效的预测价值。方法:回顾性分析2020年6月-2021年6月本院收治的CSP患者107例,根据手术治疗方式分组,分别为子宫动脉栓塞术(栓塞组51例)、宫腔镜下瘢痕病灶切除术(切除组56例)。检测两组术前、术后72h血清β-hCG、术后1个月血白细胞介素6(IL-6)、肿瘤坏死因子α(TNF-α)水平,采用ROC曲线分析β-hCG、IL-6、TNF-α对宫腔镜疗效的预测价值。结果:两组术后72h血清β-hCG水平均低于术前且切除组低于栓塞组,两组术后1个月IL-6、TNF-α水平均低于术前且切除组低于栓塞组(均P<0.05)。β-hCG、IL-6、TNF-α预测宫腔镜治疗疗效的敏感度为91.1%、73.2%、87.5%,特异度为82.4%、80.4%、45.1%,曲线下面积分别为0.956、0.833、0.816。结论:子宫瘢痕妊娠患者血β-hCG和炎性因子表达水平异常升高,宫腔镜下切除治疗可有效降低上述指标水平,且上述指标对治疗后疗效具有较高的预测价值。
Objective:To explore the expressions ofβhuman chorionic gonadotropin(β-hCG)and inflammatory factor of patients with cesarean scar pregnancy(CSP)after hysteroscopy treatment,and to study their predictive values for the efficacy of hysteroscopy treatment.Methods:107 patients with CSP treated in hospital from June 2020 to June 2021 were analyzed retrospectively.According to the surgical treatment methods,these patients were divided into control group and study group.Uterine artery embolization was performed in 51 patients in the control group and scar lesion resection under hysteroscopy was performed in 56 patients in the study group.The levels ofβ-HCG before and after surgery and interleukin 6(IL-6)and tumor necrosis factor a(TNFa)in the 1st month after surgery of the patients in the two groups were detected.The predictive values of the levels ofβ-hCG,IL-6,and TNF a of the patients for their efficacy of hysteroscopy treatment was analyzed by receiver operator characteristic(ROC)curve.Results:The serumβ-hCG level of the patients in the two groups in 72h after surgery was significantly lower than before surgery,and which of the patients in the study group was significantly lower than that of the patients in the control group.The IL-6 and TNF-a levels of the patients in the two groups in 1 month after surgery were significantly lower than those of the pa-tients before surgery,and which of the patients in the study group were significantly lower than those of the patients in the control group(all P<0.05).The sensitivity of the levels ofβ-hCG,IL-6,and TNF-a for predicting the curative effect of hysteroscopy treatment were 91.1%,73.2%,and 87.5%,respectively,and the specificity of the levels ofβ→hCG,IL-6,and TNF-a for predicting the curative effect of hysteroscopy treatment were 82.4%,80.4%,and 45.1%,respectively,and the areas under the curve of the levels ofβ-hCG,IL-6,and TNF-a for predicting the curative effect of hysteroscopy treatment were 0.956,0.833,and 0.816,respectively.Conclusion:The expression levels o
作者
文进
陈芳
陈思
WEN Jin;CHEN Fang;CHEN Si(No.990 Hospital of Joint Logistics Support Force,Zhumadian,Henan Province,463000)
出处
《中国计划生育学杂志》
2023年第5期1143-1146,共4页
Chinese Journal of Family Planning
关键词
子宫瘢痕妊娠
宫腔镜治疗
Β-人绒毛膜促性腺激素
炎性因子
疗效
Hysteroscopic treatment
Uterine scar pregnancy
βhuman chorionic gonadotropin
Inflammatory fac-tors
Curative effect
