摘要
中药赤芍具有清热凉血、散瘀止痛的功效;现代药理研究成果认为,赤芍的症靶为斑疹、吐血、衄血、瘀热型疼痛和黄疸,标靶为胆红素、转氨酶及血糖升高;此外,赤芍及其有效成分还具有心血管系统保护作用、保肝作用、抗肿瘤作用等。赤芍的综合毒性实验显示其无明显毒副作用,不具有致突变、致畸、致癌风险,但血虚有寒者及孕妇应慎服。《中华人民共和国药典》规定赤芍用量为6~12 g,医家经验用量为0.925~300 g。临床应在辨病、辨证基础上,结合症靶、标靶灵活应用。
Peony root has the efiects of clearing heat and cooling blood,resolving blood stasis and relieving pains.Combined with the modem pharmacological research achievements,it is believed that its symptom targets are macule,hematemesis and blood bleeding,pains with the heat syndrome and jaundice,while its biochemical indicator targets include elevated bilirubin,transaminase and blood glucose levels.Modem pharmacological studies have found that peony root and its effective components have the certain efiects of protecting the cardiovascular system,protecting the liver,anti-tumor,etc.The comprehensive toxicity experiments ofpeony root show that it has no obvious toxic side effects and does not have the risks ofmutagenesis,teratogenesis,or cancer,while those with blood deficiency and cold and pregnant women should take it with caution.The Pharmacopoeia ofthe Peoples Republic of China stipulates that its dosage range is 6-12 g,while the dosage range by clinical doctors is 0.925-300 g.It is suggested that peony root be applied flexibly in clinical practice on the basis of disease and syndrome differentiation and in combination with its symptom and biochemical indicator targets.
作者
张博荀
鲍慧玮
ZHANG Boxun;BAO Huiwei(Institute of Metabolic Diseases,Guang'anmen Hospital,China Academy of Chinese Medical Sciences,Beijing 100053,China;School of Pharmacy,Changchun University of Chinese Medicine,Changchun 130117,China)
出处
《吉林中医药》
2023年第5期592-595,共4页
Jilin Journal of Chinese Medicine
基金
中国科学院学部咨询评议项目(2021-ZW10-A-017)。
关键词
赤芍
态靶辨治
症靶
标靶
胆红素
黄疸
临床回归
现代中药
peony root
treatment based on state-target differentiation
symptom target
biochemical indicator target
bilirubin
jaundice
clinical verification
modem Chinese materia medica
