摘要
表观转录调控是指在不改变RNA序列的前提下,通过其可逆的化学修饰参与基因转录后调控,在多种疾病及其病理生理过程中发挥重要作用。葡萄糖和脂类是人体最主要的能量来源,糖脂内源性代谢和表达水平受到机体精准调控,其调控异常与多种代谢性疾病的发生发展密切相关。近年来研究发现,表观转录修饰,如N^(6)-甲基腺苷(m^(6)A)、5-甲基胞苷(m^(5)C)等均可通过改变关键因子的RNA二级结构、剪接、降解、稳定性等,参与糖脂代谢的调控过程。本文主要综述近年来表观转录调控参与糖脂代谢及其相关疾病的研究进展,为代谢性疾病的防治提供新思路。
Epigenetic transcriptional regulation refers to the way that genes are involved in posttranscriptional regulation through reversible chemical modification without changing RNA sequence,which plays an important role in a variety of diseases and pathophysiological processes.Glucose and lipids are the most important energy sources of the human body,and their endogenous metabolism and expression levels are precisely regulated by the body.Abnormal regulation of glucose and lipids is closely related to the occurrence and development of a variety of metabolic diseases.Recent studies have found that epigenetic transcriptional modifications such as N6-methyladenosine(m^(6)A),5-meth-cytidine(m^(5)C),are involoved in the regulation process of glucose and lipid metabolism by changing the RNA secondary structure,splicing,degradation and stability of key factors.This article mainly reviews the research progress of epigenetic transcriptional regulation involved in glucose and lipid metabolism and related diseases in recent years,so as to provide new ideas for the prevention and treatment of metabolic diseases.
作者
尹凯
覃金凤
YIN Kai;QIN Jinfeng(Guangxi Key Laboratory of Diabetic Systems Medicine,Guilin 541199;GuangxiKey Laboratory of Glycolipid Metabolism Diseases,Guilin 541199;Dept.of General Practice,the Fifth Affiliated Hospital of Southern Medical University,Guangzhou 510920,China)
出处
《华夏医学》
CAS
2023年第1期1-10,共10页
Acta Medicinae Sinica
基金
国家自然科学基金(面上项目81970390,地区项目82060065)
广西壮族自治区自然科学基金重点项目(2020GXNSFDA297011)
桂林市技术创新引导计划(20210222-3)。
