摘要
强迫行为是一种跨诊断出现的症状,但目前研究者对强迫行为的理解仍存在分歧。强迫行为可能和大脑中目标导向系统和习惯学习系统存在异常有关。然而大多研究往往只从目标导向视角出发,探究强迫行为对应的生物学机制及行为表现,较少关注习惯系统是如何影响强迫行为的。但有强迫行为的个体会表现出更多的习惯行为,异常的脑神经环路也和习惯激活的脑神经结构相重叠。从习惯出发也能够解释部分强迫行为的遗传风险因素,还能为强迫行为的药物治疗提供新视角。因此,本综述结合行为、神经生物学、基因、药理学四方面的证据,探究习惯假说在理解强迫行为方面带来的新见解,并提出当前强迫行为习惯假说中亟需解决的问题。
Compulsive behavior is a trans-diagnostic symptom.However,researchers'understanding of compulsive behavior is still argumentative.Most conventional understanding of compulsive behavior is that this symptom may be related to abnormalities in the brain goal-direct and habitual learning systems.Nevertheless,majority of studies only explore the role of goal-direct system in compulsive behavior,and they pay less attention to how the habit system affects compulsive behavior.However,individuals with compulsive behaviors will show more habitual behaviors and their abnormal brain neural circuits overlap with the brain neural structures activated by habits.Besides,starting from habit system can also explain some genetic risk factors of compulsive behavior.On top of this,habit hypothesis can bring new insights in understanding compulsive behavior from a pharmacological aspect.Therefore,in this review,the evidences from behavioral,neurobiological,genetic and pharmacological aspects were combined to explore the new insights brought by the habit hypothesis in understanding compulsive behavior,and propose the urgent problems need to be solved in current compulsive behavior habit studies.
作者
袁晨语
范尹晴
王振
Yuan Chenyu;Fan Yinqing;Wang Zhen(Shanghai Mental Health Center,Shanghai Jiao Tong University School of Medicine,Institute of Psychology and Behavioral Science,Shanghai Jiao Tong University,Shanghai 200030,China)
出处
《中华行为医学与脑科学杂志》
CAS
CSCD
北大核心
2023年第4期367-372,共6页
Chinese Journal of Behavioral Medicine and Brain Science
基金
上海市卫生健康委员会重要薄弱学科-心身医学(2019ZB0201)。
关键词
强迫行为
习惯
壳核
基因
药理学
Compulsive behavior
Habits
Putamen
Genes
Pharmacology
