摘要
由Kiss-1基因编码的Kisspeptin在下丘脑中除参与控制下丘脑-垂体-性腺(HPG)轴外,还是接收能量代谢激素/因子的信号感受器。AMPK作为机体重要的能量代谢因子,能够直接/间接作用于Kiss-1神经元,影响Kisspeptin系统的表达,进而影响生殖器官功能的正常发挥。因此,能量失衡可通过AMPK相关路径经Kisspeptin系统完成对HPG轴的调控。基于此,本文对AMPK作用于下丘脑Kiss-1神经元的机制及能量失衡后AMPK对Kisspeptin系统发挥的调节作用进行综述,以期为研究机体的能量储备与HPG轴功能及生殖功能稳态的关系提供理论依据。
Kisspeptin,encoded by the Kiss-1 gene in the hypothalamus,is involved in controlling the hypothalamic-pituitary-gonadal(HPG)axis and can receive signals from energy metabolism hormones/factors.As an important energy metabolism factor in the body,AMPK can directly or indirectly act on Kiss-1 neurons,affecting the expression of the Kisspeptin system,and the normal function of reproductive organs.Therefore,the Kisspeptin system can regulate energy imbalance through the AMPK correlation pathway.This paper reviews the mechanism of AMPK acting on Kiss-1 neurons in the hypothalamus and the regulatory effect of AMPK on the Kisspeptin system after an energy imbalance.This review aims to provide a theoretical basis for studying the relationship between the body's energy reserves,features of the HPG axis,and reproductive function homeostasis.
作者
王鹏银
徐瑞
WANG Pengyin;XU Rui(School of Sports and Health,Nanjing Sport Institute,Nanjing 210014,China)
出处
《生命的化学》
CAS
2023年第3期408-418,共11页
Chemistry of Life
基金
江苏省自然科学基金面上项目(19KJB180018)
南京体育学院重点实验室项目(SYS202102)
江苏省高等学校大学生创新创业训练计划省级创新重点项目(202210330005Z)。
