摘要
2型糖尿病是以胰岛素分泌不足及胰岛素抵抗(IR)为主要病因的异质性疾病,且常伴随着并发症的出现。挥发油是从天然植物中提取的具有挥发性的油状液体,具有理气、止痛、抑菌、消炎等多种药理作用。近年来,关于天然植物挥发油及其有效成分治疗2型糖尿病的报道层出不穷,已成为治疗2型糖尿病研究的新方向之一。该文以天然植物挥发油及其有效成分为切入点,综合分析和总结了近年来国内外挥发油治疗2型糖尿病及其并发症的物质基础、作用机制及信号通路,着重阐述了挥发油及其有效成分如香芹酚、丹皮酚、β-石竹烯等,通过保护胰岛β细胞、抑制α-葡萄糖苷酶活性、调节肠道菌群丰度及多样性,以及调控葡萄糖转运蛋白4(GLUT4)、腺苷酸活化蛋白激酶(AMPK)、磷脂酰肌醇3-激酶(PI3K)/蛋白激酶B(Akt)信号通路等多种途径抑制IR,多种作用机制改善2型糖尿病,以期为挥发油干预2型糖尿病及新型绿色降糖药的开发提供一些参考和依据。
Type 2 diabetes mellitus(T2DM)is a heterogeneous disease with insulin deficiency and insulin resistance(IR)as the main etiology and is often accompanied by complications.Volatile oil is a volatile oily liquid extracted from natural plants,which has many pharmacological effects such as regulating Qi,relieving pain,inhibiting bacteria,and reducing inflammation.In recent years,there have been numerous reports on the treatment of T2DM by natural plant volatile oil and its effective components,which has become one of the new directions in the treatment of T2DM.With natural plant essential oil and its active components as the starting point,this paper comprehensively analyzed and summarized the material basis,mechanism,and signaling pathways of essential oil in the treatment of T2DM and its complications in China and abroad in recent years,and focused on the inhibitory effect of essential oil and its active components,such as carvacrol,paeonol,andβ-caryophylene,on IR to improve T2DM by protecting pancreaticβ-cells,inhibitingα-glucosidase activity,regulating the abundance and diversity of intestinal microbiota,and regulating glucose transporter protein type4(GLUT4),adenylate 5′-monophosphate-activated protein kinase(AMPK),phosphatidylinositol-3 kinase(PI3K)/protein kinase B(Akt)signaling pathways to provide some references for the volatile oil intervention in T2DM and the development of new green antidiabetic drugs.
作者
胡付豪
梁新丽
黄小英
杨明
马广强
韩飞
HU Fuhao;LIANG Xinli;HUANG Xiaoying;YANG Ming;MA Guangqiang;HAN Fei(School of Pharmacy,Jiangxi University of Chinese Medicine,Nanchang 330004,China;Key Laboratory of Modern Chinese Herbal Preparations,Ministry of Education,Jiangxi University of Chinese Medicine,Nanchang 330004,China;School of Life Sciences,Jiangxi University of Chinese Medicine,Nanchang 330004,China)
出处
《中国实验方剂学杂志》
CAS
CSCD
北大核心
2023年第11期276-282,共7页
Chinese Journal of Experimental Traditional Medical Formulae
基金
国家自然科学基金项目(81560659,81860771)
江西省教育厅科学技术研究项目(GJJ201219)
江西省卫生健康委员会科技计划项目(202211411)
江西中医药大学博士科研启动基金项目(2018WBZR011)
大学生创新创业训练计划项目(S202110412003,202010412143,202110412003)。
