摘要
长链非编码RNA(long non-coding RNA,lncRNA)在细胞功能、生长发育和疾病发生发展等生物过程中发挥着重要作用和功能。lncRNA在心肌组织中大量表达,并参与心肌细胞中基因的控制和调节,其可以通过靶向作用,改变心肌细胞的生理功能,在缺血性心脏病(ischemic heart disease,IHD)的进程中发挥着关键作用,有望成为未来IHD诊断和治疗的新靶点,本文现就lncRNA在IHD中的研究进展做一综述。
Long non-coding RNA(lncRNA)plays an important role and has multiple functions in biological processes such as cell function,growth and development,and disease development.Lnc-RNAs are abundantly expressed in myocardial tissues and they participate in the control and regulation of a wide range of genes in cardiomyocytes.They can change the physiological functions of cardiomyocytes through targeting,and play a key role in the process of ischemic heart disease(IHD).It is expected to become a new target for the diagnosis and treatment of IHD in the future.This article reviews the research progress of lncRNA in IHD.
作者
任艳玲
苏强
REN Yanling;SU Qiang(Affiliated Hospital of Guilin Medical University,Guilin 541000,Guangxi Province,China)
出处
《解放军医学院学报》
CAS
北大核心
2023年第3期274-280,共7页
Academic Journal of Chinese PLA Medical School
基金
国家自然科学基金项目(81960079)
广西自然科学基金重点项目(2020GXNSFDA238007)。
关键词
长链非编码RNA
心肌梗死
心肌缺血再灌注损伤
心肌纤维化
心力衰竭
long non-coding RNA
myocardial infarction
myocardial ischemia-reperfusion injury
myocardial fibrosis
heart failure
