摘要
目的探讨时间窗内阿替普酶溶栓治疗急性脑梗死(ACI)的疗效及预后的影响因素分析。方法选取2019年5月-2021年3月漯河市中心医院142例ACI患者,接受时间窗内阿替普酶溶栓治疗。收集患者一般资料与入院检查结果,分析各指标与预后结果关系。结果142例患者经时间窗内阿替普酶溶栓治疗后,83例预后良好,59例预后不良。单因素分析,两组饮酒、房颤史及基线血压无统计学意义(P>0.05)。两组在性别、年龄、吸烟、合并症、发病至溶栓时间、基线NIHSS评分、血糖、低密度脂蛋白方面,差异具有统计学意义(P<0.05)。经Logistic回归分析显示,发病至溶栓时间、基线NIHSS评分、血糖与低密度脂蛋白为患者溶栓治疗预后不良的危险因素(P<0.05)。结论时间窗内阿替普酶溶栓治疗可有效提高ACI患者预后,其中发病至溶栓时间、基线NIHSS评分、血糖与低密度脂蛋白等因素为影响患者预后的危险因素。
Objective To investigate the effect and prognostic factors of thrombolytic therapy using alteplase for acute cerebral infarction(ACI)in time window.Methods A total of 142 patients with ACI in Luohe Central Hospital from May 2019 to March 2021 were enrolled,and received thrombolytic therapy using alteplase within time window.The general data and various indexes at baseline were collected,then the correlation of various indexes with prognosis was analyzed.Results Among 142 patients,83 had good prognosis and 59 had poor prognosis after thrombolytic therapy in time window.Univariate analysis showed no significant differences in alcohol consumption,history of atrial fibrillation and baseline blood pressure between groups(P>0.05),while statistical difference was found in gender,age,smoking,complications,time from onset to thrombolysis,baseline NIHSS score,blood glucose and low⁃density lipoprotein(P<0.05).Logistic regression anal⁃ysis showed that the time from onset to thrombolysis,baseline NIHSS score,blood glucose and low⁃density lipoprotein were risk factors for poor prognosis of patients with thrombolytic therapy(P<0.05).Conclusion Within the time window,thrombolysis therapy using alteplase can effectively improve the prognosis of ACI patients,among which the time from onset to thrombolysis,baseline NIHSS score,blood glucose and low⁃density lipoprotein are the risk factors affecting the prognosis of patients.
作者
李艳伟
Li Yanwei(Luohe Central Hospital,Luohe,Henan 462000)
出处
《辽宁医学杂志》
2023年第2期44-46,共3页
Medical Journal of Liaoning
关键词
时间窗
阿替普酶
溶栓治疗
急性脑梗死
疗效
预后
Time window
Alteplase
Thrombolytic therapy
Acute cerebral infarction
Clinical outcomes
Prognosis
