摘要
目的 分析不同年龄段就诊的呼吸道感染儿童的肺炎支原体(MP)感染率、性别、发病年龄分布及发病季节的流行病学特征。方法 调查2011年1月至2018年12月深圳市儿童医院住院和门诊的呼吸道感染患儿共200 055例,采用PCR方法检测咽拭子肺炎支原体DNA,采用SPSS 19.0软件进行数据处理。结果 200 055例呼吸道感染患儿中,PCR检测DNA阳性为26 833例,阳性率为13.41%;不同年龄段儿童MP阳性出率比较,差异有统计学意义(χ^(2)=4309.91,P<0.05);男女童MP阳性出率比较,差异有统计学意义(χ^(2)=31.85,P<0.05);门诊及住院儿童MP阳性出率比较,差异有统计学意义(χ^(2)=302.10,P<0.05)。MP阳性检出率夏秋季较高,主要以7至10月份较高,为18.20%~18.91%;3月份阳性检出率最低,为7.52%。2011-2018年肺炎支原体阳性检出率分别为9.27%、15.28%、24.62%、10.76%、11.65%、16.52%、9.97%%和7.69%,差异有统计学意义(P<0.05)。2016-2018年度期间住院及门诊患儿各个年龄组MP检出阳性率比较显示,小于2岁以下儿童及大于6岁以上MP感染患儿均集中在门诊,3~5岁儿童门诊阳性率与住院阳性率比较,差异无统计学意义(P>0.05)。结论 夏秋季MP阳性检出率最高,2013年阳性检出率最高,临床上应加强对肺炎支原体肺炎的检测和防治。
Objective To analyze the infection rate,gender,age distribution and epidemiological characteristics of Mycoplasma pneumoniae(MP)in children with respiratory tract infection at different ages.Methods A total of 20055 children with respiratory tract infection in inpatients and outpatients of Shenzhen Children's Hospital from January 2011 to December 2018 were investigated.The DNA of MP in pharyngeal swabs was detected by PCR and SPSS 19.0 software for data processing.Results Among the 200055 children with respiratory tract infection,26833 cases were positive for DNA detected by PCR,with a positive rate of 13.41%.There was a statistically significant difference in the positive rate of MP among children of different ages(X^(2)=4309.91,P<0.05).There was a statistically significant difference in the positive rate of MP between boys and girls(X^(2)=31.85,P<0.05).There was a statistically significant difference in the positive rate of MP between outpatient and inpatient children(X^(2)=302.10,P<0.05).The positive detection rate of MP was higher in summer and autumn,mainly from July to October,ranging from 18.20%to 18.91%.The positive detection rate was the lowest at 7.52%in March.From 2011 to 2018,the positive detection rates of MP were 9.27%,15.28%,24.62%,10.76%,11.65%,16.52%,9.97%and 7.69%,respectively,and the differences were statistically significant(P<0.05).The comparison of the positive rate of MP detection in different age groups of inpatients and outpatients during 2016-2018 shows that children under 2 years old and children over 6 years old with MP infection are concentrated in outpatient clinics.There was no statistically significant difference in the positive rate(P>0.05).Conclusion The positive detection rate of MP is the highest in summer and autumn,and the highest in 2013.Clinically,the detection and prevention of MP pneumonia should be strengthened.
作者
黄宝兴
蔡德丰
张交生
雷旻
陈运生
HUANG Baoxing;CAI Defeng;ZHANG Jiaosheng;LEI min;CHEN Yunsheng(Department of Infectious Diseases,Shenzhen Children's Hospital,Shenzhen,Guangdong,China,518026)
出处
《分子诊断与治疗杂志》
2023年第4期686-689,共4页
Journal of Molecular Diagnostics and Therapy
基金
广东省高水平临床重点专科(深圳市配套建设经费)资助(SZGSP012)。
关键词
肺炎支原体
儿童
流行病学
Mycoplasma pneumoniae
Children
Epidemiology
