摘要
脑小血管病(CSVD)是指各种病因影响脑内小血管(小动脉、微动脉、毛细血管、微静脉和小静脉)所导致的一系列临床、影像、病理综合征。CSVD的诊断主要基于影像学表现,但头颅影像学检查受到费用和出血风险等限制,使罕见CSVD的早期发现更为困难。眼底视网膜血管是唯一活体可见的血管,和脑小血管在解剖学、胚胎学上有共同的特征。已有研究表明大脑常染色体显性动脉病伴皮质下梗死和白质脑病(CADASIL)、脑淀粉样血管病(CAA)和烟雾病(MMD)等罕见CSVD均存在视网膜血管异常。视网膜血管检查可为罕见CSVD的研究发展提供新思路。
Cerebral small vessel disease(CSVD)is a series of clinical,imaging,and pathological syndromes resulting from various etiologies affecting small arteries(microarteries,capillaries,microvenules,and small veins in the brain).The diagnosis of CSVD is based on imaging presentations,but the high cost and bleeding risk of cranial imaging methods make the diagnosis of rare CSVD more difficult.Retinal vessels are the only vasculature visible in vivo and share anatomical and embryological features with small brain vessels.Retinal vascular abnormalities have been shown to exist in rare CSVD such as cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy(CADASIL),cerebral amyloid angiopathy(CAA)and moyamoya disease(MMD).Retinal vascular examination may provide new ideas for the study of rare CSVD.
作者
韦张琬钰
赵旭峰
于伟泓
Wei Zhangwanyu;Zhao Xufeng;Yu Weihong(Department of Ophthalmology,Peking Union Medical College Hospital,Chinese Academy of Medical Sciences&Peking Union Medical College Key Laboratory of Ocular Fundus Diseases,Chinese Academy of Medical Sciences,Beijing 100730,China)
出处
《中国医师杂志》
CAS
2023年第4期507-509,515,共4页
Journal of Chinese Physician
基金
新疆生产建设兵团科技计划项目(2022AB024)。
