摘要
目的探究复发性流产患者的生殖系统感染特点及引发感染的相关影响因素。方法选取新乡医学院第一附属医院产科收诊的85例复发性流产患者为研究组,同时随机选取80例同期行人工流产的健康早孕女性为对照组。于患者流产1周内,采集其宫颈分泌物,采用PCR荧光定量法检测标本中解脲脲支原体、沙眼衣原体的感染情况。研究组患者于清晨空腹状态下,抽取其静脉血,检测巨细胞病毒基因及肿瘤坏死因子、白细胞介素-1、白细胞介素-6水平。结果85例复发性流产患者研究组中,解脲脲支原体感染率、沙眼衣原体感染率、巨细胞病毒阳性率分别为29.41%(25/85)、23.53%(20/85)和16.47%(14/85)。复发性流产患者的生殖系统的解脲脲支原体感染率、沙眼衣原体感染率、巨细胞病毒阳性率显著高于对照组,差异有统计学意义(均P<0.05)。复发性流产患者中,自然流产次数3次患者的解脲脲支原体感染率、沙眼衣原体感染率、巨细胞病毒阳性率低于自然流产次数≥4次患者。随着自然流产次数增加,患者生殖系统感染率增高,差异有统计学意义(均P<0.05)。复发性流产患者的肿瘤坏死因子平均值为(21.42±4.77)ng/L,白细胞介素-1平均值为(41.66±15.78)ng/L,白细胞介素-6平均值为(152.63±29.46)ng/L。对比复发性流产患者巨细胞病毒阳性组与阴性组的炎性因子水平,炎性因子水平升高与复发性流产患者感染巨细胞病毒有关。将复发性流产患者中感染解脲脲支原体或沙眼衣原体患者与未感染患者的临床资料进行单因素分析可发现,盆腔炎、免疫异常、遗传性血栓对比差异有统计学意义(均P<0.05),子宫畸形、月经异常对比差异不具有统计学意义(均P>0.05)。进一步进行多因素分析显示,患有盆腔炎、免疫异常的复发性流产患者更易发生解脲脲支原体、沙眼衣原体感染(均P<0.05)。结论复发性流产患者的生殖�
Objective To explore the characteristics of reproductive system infection in recurrent spontaneous abortion patients and the related influencing factors of triggering infection.Methods A total of 85 recurrent spontaneous abortion patients who were admitted to the Department of Obstetrics,the First Affiliated Hospital of Xinxiang Medical College,were selected as the study group,while 80 healthy early pregnancy women who underwent induced abortion during the same period were randomly selected as the control group.The cervical secretions were collected from the patients within 1 week of abortion,and the samples were tested for Ureaplasma urealyticum and Chlamydia trachomatis by PCR fluorescence quantification.Patients in the study group were recruited from their venous blood in the early morning under a fasting condition to detect the cytomegalovirus gene and the levels of tumor necrosis factor,interleukin-1,and interleukin-6.Results In the study group of 85 recurrent spontaneous abortion patients,the prevalence of U.urealyticum infection,C.trachomatis infection,and cytomegalovirus positivity was 29.41%(25/85),23.53%(20/85),16.47%(14/85),respectively.The prevalence of U.urealyticum infection,C.trachomatis infection,and cytomegalovirus positivity in the reproductive system of recurrent spontaneous abortion patients was significantly higher than that of the control group(P0.05).The prevalence of U.urealyticum infection,C.trachomatis infection,and cytomegalovirus positivity was lower in patients with 3 spontaneous abortions than in patients with≥4 spontaneous abortions in recurrent spontaneous abortions.As the number of spontaneous abortions increased,the patients had a higher rate of genital infection,and the difference was statistically significant(P0.05).The mean values of tumor necrosis factor levels in recurrent spontaneous abortion patients were(21.42±4.77)ng/L,interleukin-1 levels were(41.66±15.78)ng/L,and interleukin-6 levels were(152.63±29.46)ng/L.Comparing the levels of inflammatory factors between the c
作者
马宁
尹山兰
王慧玲
任艳芳
徐丽娟
海晓南
MA Ning;YIN Shan-lan;WANG Hui-ling;REN Yan-fang;XU Li-juan;HAI Xiao-nan(Department of Obstetrics and Gynecology,The First Affiliated Hospital of Xinxiang Medical University,Weihui 453100,Henan,China)
出处
《中国病原生物学杂志》
CSCD
北大核心
2023年第4期465-468,共4页
Journal of Pathogen Biology
关键词
复发性流产
生殖系统
解脲脲支原体
沙眼衣原体
巨细胞病毒
recurrent spontaneous abortion
reproductive system
Ureaplasma urealyticum
Chlamydia trachomatis
cytomegalovirus
