摘要
目的对脓毒症相关性脑病(SAE)与血清S100β、NSE水平的关联性进行Meta分析。方法采用计算机检索国内外数据库,收集2021年12月以前已公开发表的关于SAE患者血清S100β、NSE水平的研究。应用RevMan 5.3、Stata 12.0软件对数据进行Meta分析。结果共纳入11篇文献,共有1054例研究对象。Meta分析结果显示:SAE患者血清S100β水平高于对照组[SMD=3.31,95%CI(2.46,4.16),Z=7.61,P<0.00001],SAE患者血清NSE水平高于对照组[SMD=2.92,95%CI(2.13,3.70),Z=7.27,P<0.00001];亚组分析结果显示:研究类型、样本检测方法、样本量大小3个因素均不是异质性的主要来源,而在诊断标准亚组中,脓毒症3.0定义和诊断标准组各研究间异质性较前下降或无统计学异质性,中国脓毒症/脓毒性休克急诊治疗指南(2014/2018)组其异质性明显下降。结论血清S100β、NSE水平升高可能会增加SAE的发生风险,动态监测其变化有助于早期发现和诊断SAE。
Objective To analyze the correlation between sepsis-associated encephalopathy(SAE)and serum S100βand NSE levels by Meta-analysis.Methods Domestic and foreign databases were searched by computer to collect studies on serum S100βand NSE levels in SAE patients published before December 2021.Meta-analysis was performed using RevMan5.3 and Stata 12.0 software.Results A total of 11 articles with 1054 subjects were included.The results of Meta-analysis showed that the serum S100βlevel of SAE patients was higher than that of the control group[SMD=3.31,95%CI(2.46,4.16)],Z=7.61,P<0.00001].Serum NSE level in SAE patients was higher than that in control group[SMD=2.92,95%CI(2.13,3.70),Z=7.27,P<0.00001].The results of subgroup analysis showed that the three factors of study type,sample detection method and sample size were not the main sources of heterogeneity.However,among the subgroups of diagnostic criteria,the heterogeneity between studies in the sepsis 3.0 definition and dignostic criteria group decreased or did not have statistical heterogeneity,and the heterogeneity between studies in the chinese sepsis/sepsis shock emergency treatment guidelines(2014/2018)group decreased significantly.Conclusion High S100βprotein and NSE levels may increase the risk of SAE,danamic monitoring of serum S100βand NSE is of great significance for early detection and diagnosis of SAE.
作者
张杏
刘传明
樊菲菲
ZHANG Xing;LIU Chuan-ming;FAN Fei-fei(Department of Emergency,Xijing Hospital,Air Force Medical University,Xi’an 710032,Shaanxi,China)
出处
《医学信息》
2023年第10期98-104,共7页
Journal of Medical Information
