摘要
目的探讨分析血清神经元特异性烯醇化酶(neuron specific enolase,NSE)、中枢神经特异蛋白(soluble protein-100β,S100β)、白细胞介素-6 (IL-6)与烧伤患者脓毒症相关性脑病(sepsis associated encephalopathy,SAE)的相关性。方法选取2015年4月至2019年6月郑州市第一人民医院收治的100例烧伤脓毒症患者作为研究对象,根据是否发生SAE将其分为SAE组22例与非SAE组78例,对比两组患者血清NSE、S100β、IL-6水平,并分析血清NSE、S100β、IL-6与SAE的相关性。结果 SAE组患者血清NSE、S100β、IL-6水平均显著高于非SAE组(t=5.334、4.111、8.623,P均=0.000);Spearman相关系数分析结果显示,血清NSE、S100β、IL-6水平与SAE均具有显著相关性(r=0.323、0.307、0.246,P=0.001、0.002、0.014)。结论血清NSE、S100β、IL-6水平与SAE具有相关性,动态监测烧伤脓毒症患者血清NSE、S100β、IL-6水平对降低SAE的发生风险具有重要意义。
Objective To explore the correlation between neuron specific enolase(NSE),soluble protein⁃100β(S100β),interleukin⁃6(IL⁃6)and sepsis associated encephalopathy(SAE)in burn patients.Methods One hundred burn patients with sepsis,admitted to The Medical Group of Zhengzhou First People’s Hospital from April 2015 to June 2019,were selected as research subjects.According to SAE occurrence,the subjects were divided into two groups:SAE group(22 cases)and non⁃SAE group(78 cases).The levels of serum NSE,S100βand IL⁃6 were respectively compared between the two groups and the correlation between serum NSE,S100β,IL⁃6 and SAE was analyzed.Results The levels of serum NSE,S100βand IL⁃6 in the SAE group were all significantly higher than that in the non⁃SAE group(t=5.334,4.111 and 8.623 respectively,all P=0000).Spearman correlation coefficient analysis showed that the lev⁃els of serum NSE,S100βand IL⁃6 were all significantly correlated with SAE(r=0.323,0.307 and 0.246 respec⁃tively,P=0.001,0.002 and 0.014 respectively).Conclusion The levels of serum NSE,S100βand IL⁃6 are correlated with SAE.Dynamic monitoring of serum NSE,S100β,IL⁃6 in burn patients with sepsis is of great signifi⁃cance for reducing the risk of SAE.
作者
赵孝开
李晓亮
肖宏涛
张健
李琰光
叶向阳
娄季鹤
夏成德
Zhao Xiaokai;Li Xiaoliang;Xiao Hongtao;Zhang Jian;Li Yanguang;Ye Xiangyang;Lou Jihe;Xia Chengde(Department of Burns,The Medical Group of Zhengzhou First People’s Hospital,Zhengzhou City,Henan 450004,China)
出处
《中国烧伤创疡杂志》
2020年第6期406-408,共3页
The Chinese Journal of Burns Wounds & Surface Ulcers
