摘要
目的探讨早期CRRT干预对行集束化治疗重症社区获得性肺炎患者实验室及预后指标的影响。方法回顾性分析我院2013年1月至2019年12月收治重症社区获得性肺炎患者共84例临床资料,其中仅给予集束化治疗共44例设为对照组,在集束化治疗基础上加用早期CRRT干预共40例设为观察组;比较两组治疗前后PCT、TNF-α、IL-6、CD4+T淋巴细胞亚群水平、ARDS发生率及死亡率。结果观察组治疗后PCT、TNF-α及IL-6水平均显著少于对照组、治疗前(P<0.05);观察组治疗后CD4+T淋巴细胞亚群水平均显著高于对照组、治疗前(P<0.05);观察组7d内ARDS发生率和死亡率显著低于对照组(P<0.05)。结论早期CRRT干预用于行集束化治疗重症社区获得性肺炎患者可有效抑制炎症细胞因子释放,增强机体免疫系统功能,并有助于改善临床预后。
Objective To investigate the influence of early CRRT intervention on laboratory and prognostic indicators in patients with severe community-acquired pneumonia undergoing bunching.Methods 84 patients with severe community-acquired pneumonia undergoing bunching were retrospectively chosen in the period from January 2013 to December 2019 in our hospital and divided into 2 groups including control group(44 cases)with bunching alone and experiment group(40 cases)with early CRRT intervention on the basis of control group;and the levels of PCT,TNF-α,IL-6,CD4+T lymphocyte subsets,incidence and mortality of ARDS before and after treatment of 2 groups were compared.Results The levels of PCT,TNF-αand IL-6 in observation group after treatment were significantly lower than those in control group and before treatment(P<0.05).The level of CD4+T lymphocyte subsets in observation group after treatment was significantly higher than that in control group and before treatment(P<0.05).The incidence and mortality of ARDS in observation group were significantly lower than those in control group(P<0.05).Conclusion Early CRRT intervention in the treatment of patients with severe community-acquired pneumonia undergoing bunching can effectively inhibit the release of inflammatory cytokines,enhance the function of immune system and be helpful to improve clinical prognosis.
作者
王道协
段文慧
梁瑞静
赵亮
李国吾
文建国
WANG Dao-xie;DUAN Wen-hui;LIANG Rui-jing;ZHAO Liang;LI Guo-wu;WEN Jian-guo(Department of Critical Care Medicine,Zhengzhou Third People's Hospital,Zhengzhou 450000,Henan Province,China;Urodynamics Center,The First Affiliated Hospital of Zhengzhou University/Henan Provincial Key Laboratory of Clinical Medicine,Zhengzhou 450000,Henan Province,China)
出处
《罕少疾病杂志》
2023年第5期35-36,共2页
Journal of Rare and Uncommon Diseases
