摘要
【目的】探讨转移相关蛋白2(MTA2)、成纤维细胞生长因子受体样蛋白1(FGFRL1)在宫颈鳞状细胞癌组织中的表达及其临床意义。【方法】选取2019年2月至2020年2月本院收治的85例宫颈鳞状细胞癌患者,收集患者癌组织和对应癌旁组织标本,采用免疫组化法检测MTA2、FGFRL1表达水平,采用计算机图像分析技术测定其积分光密度(IOD)值。比较癌组织和癌旁组织MTA2、FGFRL1的IOD值;随访2年,统计宫颈鳞状细胞癌患者预后情况,比较死亡患者与存活患者的临床特征;采用Logistic回归分析宫颈鳞状细胞癌患者预后的影响因素;采用受试者工作特征(ROC)曲线分析MTA2、FGFRL1的IOD值对宫颈鳞状细胞癌患者预后的预测价值。【结果】宫颈鳞状细胞癌患者癌组织中MTA2、FGFRL1的IOD值均高于癌旁组织(P<0.05);死亡患者淋巴结转移、分化程度构成比以及MTA2、FGFRL1的IOD值与存活患者比较,差异均有统计学意义(P<0.05)。Logistic多因素回归分析结果显示:淋巴结转移、MTA2的IOD值、FGFRL1的IOD值均是影响宫颈鳞状细胞癌患者预后的独立危险因素(P<0.05);ROC曲线分析结果显示:癌组织中MTA2、FGFRL1的IOD值预测宫颈鳞状细胞癌患者预后的最佳截断点分别为0.63和9.88,灵敏度分别为78.12%和75.00%,特异度分别为78.43%和80.39%,曲线下面积(AUC)分别为0.706和0.767,二者联合的特异度和AUC分别为96.08%和0.831。【结论】宫颈鳞状细胞癌患者癌组织MTA2、FGFRL1的IOD值均异常升高,癌组织MTA2、FGFRL1均是影响宫颈鳞状细胞癌患者预后的独立危险因素,其可作为预测患者预后的敏感指标。
【Objective】To explore the expression and clinical significance of metastasis-associated protein 2(MTA2)and fibroblast growth factor receptor-like protein 1(FGFRL1)in patients with cervical squamous cell carcinoma.【Methods】A total of 85 patients with cervical squamous cell carcinoma admitted to the hospital from February 2019 to February 2020 were selected and the cancer tissue and corresponding paracancerous tissue specimens from those cases were collected.The immunohistochemical method was used to detect the expression levels of MTA2 and FGFRL1,and their integrated optical density(IOD)was determined by computer image analysis technology.The expression levels of MTA2 and FGFRL1 in cancer tissues and adjacent tissues were compared.Deaths of patients with cervical squamous cell carcinoma were counted with 2-year follow-up,while the clinical characteristics of the dead and the surviving patients were compared.Logistic regression was used to analyze the factors affecting the death of patients with cervical squamous cell carcinoma,the receiver operating curve(ROC)was used to analyze the value of MTA2 and FGFRL1 expression levels in predicting the death of patients with cervical squamous cell carcinoma.【Results】The IOD values of both MTA2 and FGFRL1 in cancer tissues were higher than those in adjacent tissues(P<0.05).Comparing to the surviving patients,the composition ratio of lymph node metastasis,tumor differentiation degree,and both MTA2 IOD value and FGFRL1 IOD value of dead patients were significantly different(P<0.05).Logistic multivariate regression analysis showed that lymph node metastasis,MTA2 IOD value,FGFRL1 IOD value were independent risk factors affecting the death of cervical squamous cell carcinoma patients(P<0.05).ROC analysis showed that the best cut-off points for cancer tissue MTA2 and FGFRL1 IOD values to predict death of cervical squamous cell carcinoma patients were 0.63 and 9.88,respectively,whose the sensitivity were 78.12%and 75.00%,the specificity were 78.43%and 80.39%.The area un
作者
刘妮
王丽娟
LIU Ni;WANG Li-juan(Department of Gynecology,Weinan Maternal and Child Health Hospital,Weinan Shaanxi 714000)
出处
《医学临床研究》
CAS
2023年第4期523-526,共4页
Journal of Clinical Research
