摘要
目的探讨超声造影对肝细胞癌(HCC)分化程度的诊断价值及相关性。方法选取2019-06-01-2022-06-01南阳市第一人民医院门诊和住院就诊由病理确诊的100例HCC患者为研究对象,按照病理结果分为高分化组(50例)和中低分化组(50例)。分析其造影出现的特征,并找出能区分2组的增强类型;应用超声造影软件绘制时间-强度曲线,将2组有差异性的参数进行相关性分析。结果“快进慢出”的增强模式常见于高分化组,该模式在2组中比较差异有统计学意义,χ^(2)=6.08,P=0.001;以“快进慢出”作为高分化HCC诊断标准,其诊断敏感性58.0%,特异性100.0%,阳性预测值100.0%,阴性预测值70.4%。高分化组造影剂开始廓清时间为(108.65±5.21)s,较中低分化组的(75.15±3.69)s长,差异有统计学意义,t=37.103,P=0.012。时间-强度曲线中各参数比较,2组的增强斜率、增强时间、相对峰值强度以及下降斜率差异有统计学意义,均P<0.05。相关性分析发现,造影剂开始廓清时间(r=0.226,P=0.024)和增强时间(r=0.421,P=0.015)与病理分化程度呈正相关,而增强斜率(r=-0.215,P=0.031)、相对峰值强度(r=-0.339,P=0.016)以及下降斜率(r=-0.203,P=0.043)与病理分化程度呈负相关。结论超声造影可以提示HCC分化程度,以“快进慢出”对高分化HCC诊断具有很高的特异性,超声造影各参数与HCC病理分化程度有相关性。
Objective To evaluate the value and correlation of contrast-enhanced ultrasound in the diagnosis of differentiation of hepatocellular carcinoma(HCC).Methods A retrospective analysis was made on 100 patients with HCC confirmed by pathology Nanyang First People’s Hospital from June 1,2019 to June 1,2022.According to the pathological results,the patients were divided into high differentiation group(n=50)and low differentiation group(n=50).The characteristics of radiography were analyzed and the enhancement types of the two groups were found.The time-intensity curve was drawn by contrast-enhanced ultrasound software.Finally,the correlation between the two groups of parameters with differences was analyzed.Results The enhancement mode of"fast in and slow out"was common in the group of highly differentiated HCC.There was significant difference between the two groups(χ^(2)=6.08,P=0.001).If"fast in and slow out"was used as the diagnostic criterion of highly differentiated HCC,the diagnostic sensitivity,specificity and positive and negative predictive value were 58.0%,100.0%and 100.0%,70.4%respectively.The initial clearance time of contrast medium in the high differentiation group was longer than that in the middle and low differentiation group,and the difference was statistically significant[(108.65±5.21)vs(75.15±3.69)s,t=37.103,P=0.012].In the comparison of the parameters in the time-intensity curve,there were significant differences in enhancement slope,enhancement time,relative peak intensity and decline slope between the two groups(P<0.05).Correlation analysis showed that the initial clearance time(r=0.226,P=0.024)and enhancement time(r=0.421,P=0.015)of the contrast medium were positively correlated with the degree of pathological differentiation,while the enhancement slope(r=-0.215,P=0.031),relative peak intensity(r=-0.339,P=0.016)and decline slope(r=-0.203,P=0.043)were negatively correlated with the degree of pathological differentiation.Conclusion Contrast-enhanced ultrasound can indicate the differentiation
作者
方毅斌
王宏伟
周锋
FANG Yibin;WANG Hongwei;ZHOU Feng(Department of Ultrasound Medicine,Nanyang First People's Hospital,Nanyang 473000,China)
出处
《社区医学杂志》
CAS
2023年第5期250-254,共5页
Journal Of Community Medicine
关键词
肝细胞癌
超声造影
分化程度
诊断价值
相关性分析
hepatocellular carcinoma
contrast-enhanced ultrasound
degree of differentiation
diagnostic value
correlation analysis
