摘要
目的观察针刺配合康复训练治疗儿童孤独症的临床疗效。方法将86例儿童孤独症患者随机分为治疗组和对照组,每组43例。对照组采用常规康复训练治疗,治疗组在对照组基础上采用针刺治疗。观察两组治疗前后各项量表[儿童孤独症评定量表(childhood autism rating scale,CARS)、孤独症行为量表(autism behavior checklist,ABC)和婴儿-初中学生社会生活能力量表(infant-junior high school student’s social living ability scale,S-M量表)]评分、语言能力各项评分(语言表达、语言理解和语言沟通)及各项生化指标[血清组织型纤溶酶原激活剂(tissue-type plasminogenactivator,t-PA)、谷胱甘肽(glutathione,GSH)水平和全血中5-羟色胺(5-hydroxytryptamine,5-HT)水平]的变化情况,并比较两组临床疗效。结果治疗组总有效率为90.7%,明显高于对照组的76.7%(P<0.05)。两组治疗后CARS评分、ABC评分、语言能力各项评分及血5-HT水平均较同组治疗前显著下降,S-M量表评分及血清t-PA、GSH水平均显著上升,差异均具有统计学意义(P<0.05)。治疗组治疗后各项量表评分、语言能力各项评分及各项生化指标与对照组比较,差异均具有统计学意义(P<0.05)。结论针刺配合康复训练治疗儿童孤独症疗效确切,能改善患者语言能力,降低CARS评分、ABC评分,调节t-PA、GSH和5-HT水平。
Objective To observe the clinical effect of acupuncture combined with rehabilitation training in the treatment of autism in children.Method A total of 86 children with autism were randomly divided into treatment group and control group,with 43 cases in each group.The control group was treated with routine rehabilitation training,and the treatment group was treated with acupuncture in addition to the treatment used in the control group.Before and after treatment,the scores of several scales[childhood autism rating scale(CARS),autism behavior checklist(ABC),infant-junior high school student’s social living ability scale(S-M scale)],scores of language ability(language expression,language understanding,language communication)and biochemical indexes[serum tissue plasminogen activator(t-PA),glutathione(GSH)levels and 5-hydroxytryptamine(5-HT)level in whole blood]were observed in the two groups,and the clinical efficacy of the two groups was compared.Result The total effective rate of the treatment group was 90.7%,which was significantly higher than 76.7%of the control group(P<0.05).After treatment,the CARS score,ABC score,language ability score and serum 5-HT level in the two groups were significantly lower than those before treatment,the S-M scale score,serum t-PA and GSH levels were significantly higher than those before treatment,and the differences were statistically significant(P<0.05).After treatment,the scores of each scale,each score of language ability and each biochemical index in the treatment group were significantly different from those in the control group(P<0.05).Conclusion Acupuncture combined with rehabilitation training is effective in the treatment of children with autism,which can improve language ability,reduce CARS score and ABC score,and regulate the levels of t-PA,GSH and 5-HT.
作者
王静
梅雪蕊
李文霞
尚清
WANG Jing;MEI Xuerui;LI Wenxia;SHANG Qing(Henan Children’s Hospital,Zhengzhou Children’s Hospital,Zhengzhou 450053,China)
出处
《上海针灸杂志》
CSCD
2023年第5期503-507,共5页
Shanghai Journal of Acupuncture and Moxibustion
关键词
针刺疗法
康复疗法
孤独症谱系障碍
儿童孤独症评定量表
孤独症行为量表
语言能力
Acupuncture therapy
Rehabilitation therapy
Autism spectrum disorder
Childhood autism rating scale
Autism behavior checklist
Language ability
