摘要
目的:探讨中药浸泡联合5-氨基酮戊酸光动力疗法(5-aminolevulinic acid photodynamic therapy,ALA-PDT)治疗跖疣的疗效及其对调节性T细胞、转化生长因子-β(Transforming growth factor-β,TGF-β)、γ-干扰素(Interferon-γ,IFN-γ)的影响。方法:按照随机数字表法将2019年1月-2020年12月笔者医院收治的160例跖疣患者分为对照组和观察组,每组80例。对照组使用ALA-PDT(每隔20天1次,共3次),观察组使用中药浸泡(每天1次)联合ALA-PDT。比较两组的临床疗效、疣体评分、外周血CD4 ^(+)CD25 ^(+)CD127dim/-Treg水平、血清TGF-β、IFN-γ水平,不良反应及复发率。结果:观察组总有效率92.50%,明显高于对照组80.00%,差异有统计学意义(P<0.05)。治疗后,观察组的疣体评分[(0.39±0.0.4)分vs(1.05±0.16)分]、外周血CD4 ^(+)CD25 ^(+)CD127dim/-Treg水平[(6.90±1.04)×10^(5)个vs(8.72±2.58)×10^(5)个]及血清TGF-β[(0.75±0.16)ng/mlvs(1.02±0.21)ng/ml]明显低于对照组,血清IFN-γ水平[(5.63±1.14)ng/Lvs(4.09±1.02)ng/L]明显高于对照组,差异均有统计学意义(P<0.05)。观察组的复发率(5.00%)明显低于对照组(18.75%),差异有统计学意义(P<0.05)。两组不良反应发生情况比较,差异无统计学意义(P>0.05)。结论:中药浸泡联合ALA-PDT治疗跖疣疗效显著,安全性好,能有效调节免疫-炎症反应,降低复发率。
Objective To investigate the effects of Traditional Chinese Medicine(TCM)soaking combined with 5-aminolevulinic acid photodynamic therapy(ALA-PDT)on plantar warts and its effects on regulatory T cells,transforming growth factor-β(TGF-β)and interferon-γ(IFN-γ).Methods According to random number table method,a total of 160 patients with plantar warts who were divided into control group and observation group in the author's hospital from January 2019 to December 2020,with 80 patients in each group.The control group was givenALA-PDT(once every 20 days,three times in total),and the observation group was given TCM soaking(once a day)combined withALA-PDT.The clinical effcacy,warts score,peripheral blood levels of CD4 ^(+)CD25 ^(+)CD127dim/-Treg,serum levels of TGF-βand IFN-γ,adverse reactions and recurrence rates were compared between two groups.Results The total effective rates(92.50%vs 80.00%)in the observation group was significantly higher than that in the control group(P<0.05).The warts score[(0.39±0.0.4)points vs(1.05±0.16)points],peripheral blood levels of CD4 ^(+)CD25 ^(+)CD127dim/-Treg 5[(6.90±1.04)×10 vs(8.72±2.58)×10^(5)],the serum TGF-β[(0.75±0.16)ng/ml vs(1.02±0.21)ng/ml]was significantly lower than that of the control group.The serum levels of IFN-γ[(5.63±1.14)ng/L vs(4.09±1.02)ng/L]in the observation group was significantly higher than that in the control group(P<0.05).The recurrence rates(5.00%vs 18.75%)in the observation group was significantly lower than that in the control group(P<0.05).There was no significant difference in adverse reactions between the two groups(P>0.05).Conclusion TCM soaking combined withALA-PDT had significant effect and good safety on plantar warts.It could effectively regulate the immune-inflammatory response and reduce the recurrence rates.
作者
杨瑞海
王云鹏
YANG Ruihai;WANG Yunpeng(Department of Dermatology,Rizhao Institute of Dermatology,Rizhao 276800,Shandong,China)
出处
《中国美容医学》
CAS
2023年第4期111-114,共4页
Chinese Journal of Aesthetic Medicine
关键词
跖疣
5-氨基酮戊酸光动力疗法
中药浸泡
调节性T细胞
转化生长因子-Β
干扰素-Γ
plantar warts
5-aminolevulinic acid photodynamic therapy
traditional chinese medicine soaking
regulatory T cells
transforming growth factor-β
interferon-γ
