摘要
目的探讨儿童上消化道疾病的临床特点,幽门螺杆菌(Hp)感染与胃及十二指肠黏膜病变的关系。方法回顾性分析802名患儿既接受电子胃镜检查又进行Hp的检测,使用倾向评分匹配分析(PSMA)对2组患儿进行了回顾性评估。2组患儿使用1∶1及PS得分为0.02以内的就近匹配原则。经PSMA后产生206个匹配对。结果406例患儿中,非Hp感染组年龄(8.37±1.23)岁、Hp感染组年龄(10.63±2.21)岁,随着年龄增长,Hp感染率增加。Hp感染组以呕血、黑便起病的发生率明显高于非Hp感染组(P<0.05)。Hp感染组在胃镜检查结果中浅表性胃炎、浅表性胃炎伴糜烂、胃(窦)溃疡、十二指肠溃疡的发生率明显高于非Hp感染组。结论Hp感染率与年龄呈正相关关系,儿童胃十二指肠疾病与Hp感染密切相关,尤其以胃、十二指肠溃疡与Hp感染关系更为密切。
Objective To explore the clinical features of upper gastrointestinal diseases in children,and to explore the relationship between Helicobacter pylori(Hp)infection and gastric and duodenal mucosal lesions.Methods A total of 802 children underwent both electronic gastroscopy and Hp test in a retrospective analysis.The propensity score matching analysis(PSMA)was used to retrospectively evaluate the two groups of children.PSMA was used for multivariate logistic regression to complete the model based on:age,gender,inspection season,residential area,state at the time of inspection(normal,painless).For the two groups of patients,the nearest matching principle of 1∶1 and PS score within 0.02 was used.After PSMA,206 matching pairs were generated.Results Among the 406 children,the age of the non-Hp infection group was(8.37±1.23)years old,and the age of the Hp infection group was(10.63±2.21)years old,suggesting that with age,the Hp infection rate increased.The incidence of onset of hematemesis and melena in the Hp infection group was significantly higher than that in the non-Hp infection group,and the differences were statistically significant.The incidence of superficial gastritis,superficial gastritis with erosion,gastric(antral)ulcer,and duodenal ulcer in the HP infection group was significantly higher than that of the non-Hp infection group.Conclusion Hp infection rate is positively correlated with age.Children's gastroduodenal diseases are closely related to Hp infection,especially gastric and duodenal ulcers are more closely related to Hp infection.
作者
马小龙
刘春霞
马金海
MA Xiaolong;LIU Chunxia;MA Jinhai(Pediatrics Department,General Hospital of Ningxia Medical University,Yinchuan 750004,China)
出处
《宁夏医学杂志》
CAS
2023年第4期332-334,共3页
Ningxia Medical Journal
