摘要
目的评估湖南省医疗机构工作人员抗肿瘤药物(ADs)职业暴露的基本情况,为制定ADs职业暴露防控措施提供依据。方法采用自行设计的问卷,对湖南省19家三级甲等医院接触ADs相关科室的医生、护士、药师、行政人员、工人进行问卷调查,调查内容包括基本情况、ADs接触及防护情况、认知及培训情况、自身健康情况。结果共发放问卷588份,有效回收539份,有效回收率为91.67%。539名调查对象中,职业以护士(46.75%)为主,工作科室以肿瘤科最多(31.17%),年龄以30~39岁为主(46.94%),女性较多(80.15%),本科学历占比最高(63.82%),中级职称最多(47.31%),工作年限以6~10年为主(29.87%);接触较多的ADs有顺铂(78.11%)、环磷酰胺(73.10%);不同科室及不同职业工作人员接触ADs的频率均存在显著差异(P<0.001),血液科(72.97%)、护士(55.16%)频繁接触ADs的比例最高;8.01%的工作人员所在科室未配备任何防护装置,1.91%的工作人员在接触ADs时不使用任何个人防护装备;不同科室工作人员对ADs及职业暴露的认知情况存在显著差异(P<0.001),肿瘤科、静脉用药调配中心、血液科的认知程度相对较高;不同职业工作人员对ADs的作用机制、吸收途径、接触后的处理方式的认知存在显著差异(P≤0.001),医生、护士、药师的认知程度相对较高;25.97%的工作人员未接受过相关培训;不同科室、职业的工作人员在接触ADs后出现自身健康问题的情况存在显著差异(P<0.001),血液科(54.05%)、护士(35.71%)出现健康问题比例最高;出现较多的健康问题为脱发增多(34.60%),口腔炎、口腔溃疡(13.50%),月经异常(13.08%);316名已婚女性员工中,43例(13.61%)出现过不孕,14例(4.43%)出现过习惯性流产,94例(29.75%)有过人工流产,32例(34.04%)人工流产的原因为胎儿发育问题。结论医疗机构存在ADs职业暴露的风险,工作人员要提高对ADs职业暴露的认知;医疗机构要加强管理,强
Objective To evaluate the general situation of occupational exposure to antineoplastic drugs(ADs)in medical institutions in Hunan Province,and to provide basis for formulating prevention and control measures of ADs occupational exposure.Methods A self-designed questionnaire was used to investigate doctors,nurses,pharmacists,administrators and work-ers in Ads-related departments of 19 grade A hospitals in Hunan Province.The survey contents included the general informa-tion,ADs exposure and protection,cognition and training,and health status.Results A total of 588 questionnaires were sent out,and 539 were effectively recovered,with an effective recovery of 91.67%.Among the 539 respondents,46.75%were nurses,and most of them were female staff members(80.15%).Respondents aged from 30 to 39(46.94%),from oncology department(31.17%),with bachelor degree(63.82%),with intermediate professional titles(47.31%),working for 6~10 years(29.87%)ac-counted for the highest proportion.ADs of more exposure were cisplatin(78.11%),cyclophosphamide(73.10%).There were significant differences in the frequency of ADs exposure among staffs in different departments and occupations(P<0.001).He-matology department staff(72.97%)and nurses(55.16%)had the highest frequency of ADs exposure.8.01%of the respon-dents were not equipped with any protective devices in their department.1.91%of the respondents did not use any personal protective equipment when exposed to Ads.There were significant differences in cognition of ADs and occupational exposure among respondents from different departments(P<0.001),and the cognition degree of respondents from oncology department,pharmacy intravenous admixture service(PIVAS)and hematology department was relatively higher.There were significant dif-ferences in cognition of the mechanism,absorption pathway and post-exposure treatment of ADs among the respondents with different occupations(P≤0.001),and doctors,nurses and pharmacists had relatively higher degree of cognition.25.97%of the respondents received no rele
作者
王鹏
符一岚
李沁璇
胡雅雯
谢智勇
何益锋
WANG Peng;FU Yilan;LI Qinxuan;HU Yawen;XIE Zhiyong;HE Yifeng(School of Pharmaceutical Sciences(Shenzhen),Sun Yat-sen University,Shenzhen,518107,Guangdong,China;Department of Pharmacy,the First People’s Hospital of Changde,Changde,415000,Hunan,China;De-partment of Pharmacy,Hunan Cancer Hospital,Changsha,410013,Hunan,China;Admission Preparation Center,the First People’s Hospital of Changde,Changde,415000,Hunan,China)
出处
《肿瘤药学》
CAS
2023年第2期233-240,共8页
Anti-Tumor Pharmacy
基金
国家自然科学基金面上项目(82174104)
长沙市科学技术局2020年第一批重点研发、平台和人才科技计划项目(kq2004131)。
关键词
湖南省
医疗机构
抗肿瘤药物
职业暴露
问卷调查
Hunan province
Medical institutions
Antineoplastic drugs
Occupational exposure
Questionnaire investigation
