摘要
目的:评估小细胞肺癌(small cell lung cancer,SCLC)患者原发灶^(18)F⁃FDG PET/CT代谢参数与外周血炎症标志物之间的相关性。方法:回顾性分析2014年1月—2019年12月于南京医科大学第一附属医院核医学科行PET/CT检测且未行任何治疗的SCLC患者,收集PET/CT检查前1周内的血清炎症标志物[中性粒细胞与淋巴细胞比值(neutrophil/lymphocyte ratio,NLR)、血小板与淋巴细胞比值(platelet/lymphocyte ratio,PLR)、单核细胞与淋巴细胞比值(monocyte/lymphocyte ratio,MLR)及全身免疫炎症指数(systemic immune⁃inflammation index,SII)]、临床资料及原发灶PET/CT代谢参数[最大标准摄取值(maximum standardized uptake value,SUVmax)、平均标准摄取值(mean standardized uptake value,SUVmean)、肿瘤代谢体积(metabolic tumor volume,MTV)和病灶糖酵解总量(total lesion glycolysis,TLG)]数据,通过Spearman检验分析它们之间的相关性。结果:56例SCLC患者的血清炎症标志物NLR、PLR、MLR、SII与原发灶PET/CT部分代谢参数[TLG(rNLR=0.309,rPLR=0.304,rMLR=0.271,rSII=0.362),MTV(rNLR=0.354,rPLR=0.341,rMLR=0.290,rSII=0.411)]之间存在轻度正相关性(P均<0.05),而与原发灶的SUVmax及SUVmean均无显著相关性(P均>0.05)。广泛期SCLC患者NLR、MLR、SII、中性粒细胞及原发灶PET/CT部分代谢参数(MTV、TLG)的水平高于局限期,广泛期淋巴细胞低于局限期(P均<0.05),而其余原发灶的代谢参数(SUVmax、SUVmean)、PLR、单核细胞及血小板在SCLC广泛期和局限期中无统计学差异(P均>0.05)。结论:SCLC基线NLR、SII、MLR可能不仅反映全身炎症情况,而且反映肿瘤病灶以^(18)F⁃FDG活性为代表的炎症情况。对NLR、MLR和SII增高的SCLC患者而言,可能有必要通过PET/CT检查进行分期,从而调整后续的治疗方案。
Objective:The current study aims to evaluate the correlation between inflammatory markers and^(18)F⁃fluorodeoxyglucose(FDG)positron emission tomography/computed tomography(PET/CT)metabolic parameters in patients with small cell lung cancer(SCLC)at baseline.Methods:A total of 56 SCLC patients,who underwent^(18)F⁃FDG PET/CT and did not receive any treatment in Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University between January 2014 and December 2019,were analyzed retrospectively.The inflammatory markers[neutrophil/lymphocyte ratio(NLR),platelet/lymphocyte ratio(PLR),monocyte/lymphocyte ratio(MLR)and systemic immune⁃inflammation index(SII)],clinical data and metabolic parameters of primary tumor[maximum standardized uptake value(SUVmax),mean standardized uptake value(SUVmean),metabolic tumor volume(MTV),TLG(total lesion glycolysis)]within one week before PET/CT detection were collected to analyze the correlation by Spearman’s rho test.Results:The slight positive correlations were found between inflammatory markers(NLR,PLR,MLR,SII)and partial metabolic parameters[TLG(rNLR=0.309,rPLR=0.304,rMLR=0.271,rSII=0.362),MTV(rNLR=0.354,rPLR=0.341,rMLR=0.290,rSII=0.411)]of primary tumor in 56 patients with SCLC(all P<0.05).The SUVmax and SUVmean were not found to be correlated with these hematological parameters(all P>0.05).The neutrophils,NLR,MLR,SII,MTV and TLG in extensive stage were higher than those in limited stage,and the lymphocytes in extensive stage were lower than those in limited stage(all P<0.05),but SUVmax,SUVmean,PLR,monocytes and platelets were not found differences between extensive and limited stage(all P>0.05).Conclusion:Baseline NLR,MLR,SII of SCLC not only reflect the systemic metabolism,but also reflect the local inflammation of tumor.It may be necessary to receive whole⁃body PET/CT for staging to adjust treatment strategy in those patients with high NLR or MLR,SII.
作者
胡瑶
孙晋
HU Yao;SUN Jin(Department of PET/CT Center,Jiangsu Cancer Hospital,the Affiliated Cancer Hospital of Nanjing Medical University,Jiangsu Institute of Cancer Research,Nanjing 210009;Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报（自然科学版）》
CAS
北大核心
2023年第4期536-541,共6页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省肿瘤医院院基金项目(ZJ202122)
江苏省卫生计生委面上课题(H2018029)。
