摘要
目的:探讨肺小细胞癌中18F-FDG PET/CT的各项代谢参数与神经内分泌标志物(Syn、CgA、CD56)、TTF-1、Ki-67表达的相关性及其预后价值。方法:回顾性分析南京医科大学第一附属医院2009年1月—2017年5月经病理证实的96例肺小细胞癌的免疫组化及18F-FDG PET/CT显像资料。结果:96例肺小细胞癌的原发灶最大标准摄取值(primary lesion maximum standardized uptake value,PSUVmax)、总病灶代谢体积(whole body lesion metabolic tumor volume,WBMTV)、总病灶糖酵解总量(whole body lesion glycolysis,WBTLG)分别为10.30(1.20~42.90)、108.44(0.41~710.40)cm3、585.73(1.30~10668.50),TTF-1阴性组与阳性组的PSUVmax、WBMTV、WBTLG差异有统计学意义(Z=-3.063、-2.235、-2.538,P=0.002、0.025、0.011);PSUVmax值与Ki-67的表达呈正相关(r=0.620,P<0.05);单因素生存分析表明TTF-1、CD56、WBMTV、WBTLG与总生存期(overall survival,OS)相关(HR值:0.477、0.090、2.862、2.795,P均<0.05);多因素生存分析显示CD56及WBMTV是OS的独立预后因素(HR值:0.092、1.007,P均<0.05)。结论:肺小细胞癌中18F-FDG PET/CT显像的各项代谢参数与TTF-1、Ki-67的表达具有较好的相关性,而与神经内分泌标志物无明显相关性;CD56及WBMTV是OS的独立预后因素。
Objective:This study aims to investigate the correlation between the metabolic parameters of18 F-FDG PET/CT and the expression of neuroendocrine markers(Syn,CgA,CD56),TTF-1 and Ki-67,and the value of prognosis in small cell lung cancer(SCLC).Methods:The immunohistochemical data and18 F-FDG PET/CT data of 96 SCLC cases confirmed by pathology were retrospectively analyzed,the cases collected from January 2009 to May 2017 in the First Affiliated Hospital of Nanjing Medical University.Results:The median of primary lesion maximum standardized uptake value(PSUVmax),whole body lesion metabolic tumor volume(WBMTV)and whole body lesion glycolysis(WBTLG)in 96 SCLC patients were 10.30(1.20~42.90)、108.44(0.41~710.40)cm3、585.73(1.30~10668.50);the values of PSUVmax,WBMTV and WBTLG had statistically significant differences between the negative and positive groups of TTF-1(Z=-3.063,-2.235,-2.538,P=0.002,0.025,0.011).The Spearman correlation analysis shows that there was a positive correlation between PSUVmaxand Ki-67 expression(r=0.620,P<0.001).Kaplan-Meier single factor analysis shows the expression of TTF-1 and CD56,WBMTV,WBTLG was significantly correlated with overall survival(HR:0.477,0.090,2.862,2.795,all P<0.05).Multivariate survival analysis showed that CD56 and WBMTV were independent prognostic factors of overall survival(OS).Conclusion:The metabolic parameters of18 F-FDG PET/CT in SCLC had a good correlation with the expressions of TTF-1 and Ki-67,and no correlation with neuroendocrine markers.CD56 and WBMTV were the independent prognostic factors of OS.
作者
高珂梦
李天女
丁重阳
赵敏
唐立钧
GAO Kemeng;LI Tiannv;DING Chongyang;ZHAO Min;TANG Lijun(Department of Nuclear Medicine,the First Affiliated Hospital of Nanjing Medical University,Nanjing 210029,China)
出处
《南京医科大学学报（自然科学版）》
CAS
CSCD
北大核心
2020年第12期1855-1859,共5页
Journal of Nanjing Medical University(Natural Sciences)
基金
江苏省卫生计生委基金项目(Z201502)
