摘要
目的 探讨以甘油、丙醇为防冻剂的复方过氧化物消毒剂低温消毒效果。方法 采用载体定量杀菌试验和物体表面模拟现场消毒试验,分析该复方消毒剂在低温下的消毒效果与安全性。结果 在-20、-10、20℃恒温条件下,该复方过氧化物消毒剂对载体上的大肠埃希菌、金黄色葡萄球菌以及脊髓灰质炎病毒的杀灭对数值均>3;在-20、10℃冷库中该复方过氧化物消毒剂对不同位置染菌载体上的金黄色葡萄球菌和大肠埃希菌杀灭对数值均>3。安全性评价试验显示该复方过氧化物消毒剂小鼠急性经口毒性半数致死量(LD50)值大于5 000 mg/kg,对家兔皮肤无刺激,对小鼠体内染色体无损伤作用。结论 以甘油、丙醇为防冻剂的复方过氧化物消毒剂在低温下对细菌繁殖体、病毒具有较强的杀灭效果,且安全、无毒性。
Objective To analyze the low-temperature disinfection effect of a compound peroxide disinfectant using glycerol and propanol as antifreeze agents.Methods Carrier quantitative germicidal test and object surface simulation on-site disinfection test were performed to analyze the disinfection effect and safety of the compound disinfectant at low temperatures.Results At constant temperatures of-20℃,-10℃and 20℃,the logarithmic killing values of the compound peroxide disinfectant on Escherichia coli,Staphylococcus aureus and poliovirus on the carriers were>3.In cold storage at-20℃and 10℃,logarithmic killing values of the compound peroxide disinfectant on both Staphylococcus aureus and Escherichia coli on the carriers at different sites were>3.The safety evaluation test showed that the acute oral toxicity lethal dose(LD 50)value of the compound disinfectant in mice was greater than 5000 mg/kg.It did not cause irritation to rabbit skin,and had no damage on mouse chromosome.Conclusion The compound peroxide disinfectant with glycerol and propanol as antifreeze agents has a strong killing effect on bacterial propagules and viruses at low temperature,and is safe and non-toxic.
作者
蔡慧玲
吴启鹏
李家祺
胡佳
廖如燕
CAI Hui-ling;WU Qi-peng;LI Jia-qi;HU Jia;LIAO Ru-yan(Guangzhou Customs Techno-logy Center,Guangzhou 510423,China)
出处
《中国感染控制杂志》
CAS
CSCD
北大核心
2023年第5期522-526,共5页
Chinese Journal of Infection Control
基金
2021年海关总署科技计划项目(2021HK142)
2021广州海关科技计划项目(2021GZCK05)。
关键词
过氧化物
低温消毒
消毒效果
安全性
peroxide
low temperature disinfection
disinfection effect
safety
