摘要
目的:研究莫西沙星氯化钠联合头孢哌酮/舒巴坦对慢性阻塞性肺疾病(COPD)并发感染性肺炎患者的治疗效果。方法:选择2019年1月—2021年6月于宿迁市中医院就诊的106例COPD并发感染肺炎患者,应用随机数表法分为两组,各53例。对照组在常规治疗基础上加用盐酸莫西沙星氯化钠注射液,观察组在对照组基础上加用头孢哌酮/舒巴坦。记录并对比两组临床疗效、症状消失时间、病原菌清除情况,对两组患者的免疫功能指标和炎症因子进行检测,并对治疗期间患者的不良反应进行记录。结果:观察组临床疗效优于对照组,差异有统计学意义(P<0.05)。观察组患者的体温恢复正常时间、咳嗽消失时间、湿啰音消失时间、白细胞计数恢复时间早于对照组,差异有统计学意义(P<0.05)。治疗后,观察组患者的第1秒用力呼气容积占预计值百分比(FEV_(1)%pred)和最大自主通气量占预计值百分比(MVV%pred)、最大呼气中期流速(MMEF)较对照组高,差异有统计学意义(P<0.05)。治疗后,观察组患者的降钙素原(PCT)、超敏C反应蛋白(hs-CRP)、肿瘤坏死因子-α(TNF-α)水平低于对照组,差异有统计学意义(P<0.05)。治疗后,两组CD4^(+)和CD4^(+)/CD8^(+)较治疗前升高,CD8^(+)较治疗前下降,并且观察组优于对照组,差异有统计学意义(P<0.05)。两组患者的不良反应比较差异无统计学意义(P>0.05)。结论:莫西沙星氯化钠联合头孢哌酮/舒巴坦治疗COPD并发感染性肺炎效果明显,对机体炎症因子水平有降低作用,对患者免疫功能有改善作用,进而改善患者的肺功能。
Objective:To study the therapeutic effect of Moxifloxacin and Sodium Chloride combined with Cefoperazone/Sulbactam in patients with chronic obstructive pulmonary disease(COPD)complicated with infectious pneumonia.Method:A total of 106 patients with COPD complicated with pneumonia who admitted to Suqian Traditional Chinese Medicine Hospital from January 2019 to June 2021 were selected.They were randomly divided into two groups according to the random number table method,53 cases in each group.The control group was additionally given Moxifloxacin Hydrochloride and Sodium Chloride Injection on the basis of conventional treatment,and the observation group was additionally given Cefoperazone/Sulbactam on the basis of control group.The clinical efficacy,symptom disappearance time and pathogen clearance of the two groups were recorded and compared.The immune function indexes and inflammatory factors of the two groups were detected,and the adverse reactions of the patients during the treatment were recorded.Result:After treatment,the clinical effect of the observation group was better than that of the control group,the difference was statistically significant(P<0.05).In the observation group,the temperature recovery to normal time,cough disappearance time,wet rales disappearance time,white blood cell count recovery time of cough were earlier than those in the control group,the differences were statistically significant(P<0.05).After treatment,the percentage of forced expiratory volume in one second(FEV_(1)%pred),the percentage of maximal voluntary ventilation in the predicted value(MVV%pred)and the maximum middle expiratory flow rate(MMEF)in the observation group were higher than those in the control group,the differences were statistically significant(P<0.05).After treatment,the levels of procalcitonin(PCT),hypersensitive C-reactive protein(hs-CRP)and tumor necrosis factor-α(TNF-α)in observation group were lower than those in control group,and the differences were statistically significant(P<0.05).After treatment,CD4^
作者
彭雪
PENG Xue(Suqian Traditional Chinese Medicine Hospital,Suqian 223800,China)
出处
《中外医学研究》
2023年第10期51-55,共5页
CHINESE AND FOREIGN MEDICAL RESEARCH
