摘要
目的分析脑卒中后抑郁发生的影响因素,探讨血清胆红素和超敏C反应蛋白变化对卒中后抑郁的影响。方法选取青海省人民医院2019年12月至2020年12月住院治疗的脑卒中患者199例,根据长居地不同将其分为西宁城区组(海拔2000~3000 m,n=165)及州县组(海拔>3000 m,n=34);根据是否发生卒中后抑郁分为卒中后抑郁组(n=56,其中西宁城区组45例,州县组11例)、无卒中后抑郁组(n=143,其中西宁城区组120例,州县组23例)。采用相关量表评估两组神经功能缺损及抑郁程度,分别检测血清总胆红素、直接胆红素与超敏C反应蛋白水平,并进行相关性分析。结果卒中后抑郁组血清总胆红素、直接胆红素、超敏C反应蛋白分别为(19.95±7.22)mmol/L、(3.98±1.49)mmol/L、(1.40±2.29)mg/L,均显著高于无卒中后抑郁组的(16.20±7.61)mmol/L、(3.19±1.62)mmol/L、(0.63±1.33)mg/L,差异均有统计学意义(t=3.17、3.18、2.35,均P<0.05);轻-中度、重度抑郁脑卒中患者血清超敏C反应蛋白水平差异均有统计学意义(t=2.48,P<0.05)。结论血清胆红素及超敏C反应蛋白在卒中后抑郁发病过程中占重要地位,且两者有显著相关性。
Objective To analyze the influential factors of post-stroke depression and investigate the effects of changes in serum bilirubin and high-sensitivity C-reactive protein on post-stroke depression.Methods A total of 199 patients with stroke admitted to Qinghai Provincial People's Hospital from December 2019 to December 2020 were included in this study.These patients were divided into the Xining urban group(2000-3000 meters above sea level;n=165)and the Xining prefecture and county group(over 3000 meters above sea level;n=34)according to their long-term residence.They were also divided into the post-stroke depression group(n=56,including 45 patients in the Xining urban group and 11 patients in the Xining prefecture and county group)and non-post-stroke depression group(n=143,including 120 patients in the Xining urban group and 23 patients in the Xining prefecture and county group).Related scales were used to evaluate neurologic deficits and the degree of depression in the two groups.Serum levels of total bilirubin,direct bilirubin,and high-sensitivity C-reactive protein were measured in each group.Neurologic deficits and the degree of depression were correlated with serum levels of total bilirubin,direct bilirubin,and high-sensitivity C-reactive protein.Results Serum levels of total bilirubin,direct bilirubin,and high-sensitivity C-reactive protein in the post-stroke depression group were(19.95±7.22)mmol/L,(3.98±1.49)mmol/L,and(1.40±2.29)mg/L,respectively,which were significantly higher than(16.20±7.61)mmol/L,(3.19±1.62)mmol/L,and(0.63±1.33)mg/L in the non-post-stroke depression group(t=3.17,3.18,2.35,all P<0.05).There was a significant difference in serum level of high-sensitivity C-reactive protein between stroke patients with mild and moderate depression and stroke patients with severe depression(t=2.48,P<0.05).Conclusion Serum levels of bilirubin and high-sensitivity C-reactive protein play an important role in the pathogenesis of post-stroke depression and there is a significant correlation between the two
作者
张波
李娜
高雁青
郭祥星
李晓冬
Zhang Bo;Li Na;Gao Yanqing;Guo Xiangxing;Li Xiaodong(Department of Neurology,Qinghai Provincial People's Hospital,Xining 810000,Qinghai Province,China)
出处
《中国基层医药》
CAS
2023年第4期481-485,共5页
Chinese Journal of Primary Medicine and Pharmacy
关键词
卒中
抑郁
胆红素
C反应蛋白质
统计学
非参数
因素分析
统计学
Stroke
Depression
Bilirubin
C-Reactive protein
Statistics,nonparametric
Factor analysis,statistical
