摘要
辅助性T17细胞(Th17)/调节性T细胞(Treg)平衡对维持机体正常免疫功能发挥重要作用,有利于机体的免疫稳态。Th17/Treg细胞失衡影响免疫稳态的细胞因子而导致的免疫紊乱在类风湿关节炎的发病中发挥着重要作用。通过研究Th17/Treg细胞失衡状态及其产生的相关因子是开展类风湿关节炎病理机制及防治药物的相关药理研究的途径之一。近年来,以中药调控Th17/Treg细胞失衡来防治类风湿关节炎研究已开展了大量的研究。该文通过总结中药及其有效成分调控类风湿关节炎Th17/Treg细胞失衡及其相关因子的研究成果,为类风湿关节炎的基础研究、中药新药研发和临床治疗提供借鉴。
The balance of T helper type 17 cell(Th17)/T regulatory cell(Treg) plays a significant role in maintaining normal immune function of the body, and it helps maintain immune homeostasis of the organism.Imbalance of Th17/Treg cell affects cytokines of the immune homeostasis and may cause immune disorders,which plays an important role in the pathogenesis of rheumatoid arthritis. The study of Th17/Treg cell equilibrium state as well as the related factors of rheumatoid arthritis is one of the ways for pathological mechanism of rheumatoid arthritis and related pharmacological studies of preventing drug. In recent years, many studies have been carried out on regulating the balance of Th17/Treg cell with Chinese medicine to prevent and treat rheumatoid arthritis. This paper summarizes research results of Chinese medicine and its effective components for regulating the balance of Th17/Treg cell and its related factors in rheumatoid arthritis. It provides references for basic research of rheumatoid arthritis,development of new Chinese medicine and clinical treatment.
作者
杨天宁
杨会军
金芳梅
胡乐乐
杨娟娟
王爱华
苏小军
王海东
YANG Tianning;YANG Huijun;JIN Fangmei;HU Lele;YANG Juanjuan;WANG Aihua;SU Xiaojun;WANG Haidong(Gansu University of Traditional Chinese Medicine,Lanzhou 730000 Gansu,China;Center of Rheumatic Osteopathy,Gansu Province Hospital of Traditional Chinese Medicine,Lanzhou 730000 Gansu,China)
出处
《中药新药与临床药理》
CAS
CSCD
北大核心
2023年第4期564-570,共7页
Traditional Chinese Drug Research and Clinical Pharmacology
基金
国家自然科学基金项目(82260880)
国家重点研发计划项目(2018YFC1705202,2018YFC1705203)
甘肃省中医药项目(GZKP-2021-12,GZKZ-2021-3)
兰州市科技指导性计划项目(2020-ZD-32
2022-ZD-73)
王海东甘肃省名中医传承工作室建设项目。
关键词
中药
有效成分
类风湿关节炎
免疫疾病
免疫细胞
TH17/TREG细胞
炎症因子
traditional Chinese medicine
active components
rheumatoid arthritis
immune disease
immune cells
Th17/Treg cells
inflammatory cytokines
