摘要
目的分析性激素联合癌胚抗原对乳腺癌患者淋巴结转移的诊断价值。方法收集2020年8月至2021年9月在山西医科大学第二医院行根治性手术切除的乳腺癌患者52例,经腋窝淋巴结超声检查后将其分为淋巴结未转移组与转移组。收集患者血液标本,获得血清并检测血清雌二醇、睾酮、孕酮及癌胚抗原水平,分析上述指标对患者淋巴结转移的诊断价值,借助Logistic风险回归模型分析手术切除后患者发生淋巴结转移的独立危险因素。结果未转移组患者与转移组患者肿瘤最大直径及是否绝经差异有统计学意义(均P<0.05),其余一般资料差异无统计学意义(均P>0.05)。未转移组患者血清雌二醇水平为(153.97±35.55)pg/ml、孕酮水平(0.33±0.05)ng/ml、癌胚抗原水平(11.44±3.77)ng/ml,转移组患者雌二醇水平为(207.19±52.11)pg/ml(t=4.13,P<0.001)、孕酮水平(0.38±0.04)ng/ml(t=4.01,P<0.001)、癌胚抗原水平(15.41±3.46)ng/ml(t=3.94,P<0.001),转移组患者以上3个指标显著升高。雌二醇曲线下面积为0.83,孕酮曲线下面积为0.80,癌胚抗原曲线下面积为0.77,3者联合的曲线下面积为0.85,3者联合的曲线下面积最大。Logistic风险回归模型显示雌二醇、孕酮、癌胚抗原水平是影响乳腺癌患者淋巴结转移的独立危险因素(均P<0.05)。结论性激素雌二醇、孕酮联合癌胚抗原对乳腺癌患者淋巴结转移有较高诊断价值,可独立预测乳腺癌患者是否发生淋巴结转移。
Objective To analyze the diagnostic value of sex hormone combined with carcinoembryonic antigen on lymph node metastasis in breast cancer patients.Methods 52 cases of breast cancer patients who underwent surgical resection were collected and divided into non-metastasis group and metastases group after axillary lymph node ultrasonography.The blood samples was collected from patients and the levels of serum estradiol,testosterone,progesterone and carcinoembryonic antigen were detected;The diagnostic value of the above indexes in patients with lymph node metastasis was analyzed;Logistic risk regression model was used to analyze the independent risk factors for lymph node metastasis after surgical resection.Results There were significant differences between the non-metastatic group and the metastatic group in the largest tumor diameter and menopause(all P<0.05),but there were no significant differences among other general data(all P>0.05).The serum estradiol level in the non-metastatic group was(153.97±35.55)pg/ml,the progesterone level was(0.33±0.05)ng/ml,and the carcinoembryonic antigen level was(11.44±3.77)ng/ml,while the estradiol level in the metastatic group was(207.19±52.11)pg/ml(t=4.13,P<0.001),progesterone level(0.38±0.04)ng/ml(t=4.01,P<0.001),carcinoembryonic antigen level(15.41±3.46)ng/ml(t=3.94,P<0.001).The above three indicators were significantly increased in patients in the transfer group.The area under the curve of estradiol was 0.83,the area under the curve of progesterone was 0.80,the area under the curve of carcinoembryonic antigen was 0.77,the area under the curve of the combination of the three was 0.85,and the area under the curve of the combination of the three was the largest.Logistic risk regression model showed that estradiol,progesterone,and carcinoembryonic antigen levels were independent risk factors affecting lymph node metastasis in breast cancer patients(all P<0.05).Conclusion The sex hormone estradiol,progesterone combined with carcinoembryonic antigen has a high diagnostic valu
作者
郭秀芳
刘志鹏
李超
胡耀峰
朱爱萍
Guo Xiufang;Liu Zhipeng;Li Chao;Hu Yaofeng;Zhu Aiping(Clinical Laboratory,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China;Clinical Laboratory,Shanxi Provincial Hospital of Traditional Chinese Medicine,Taiyuan 030012,China;Department of Breast surgery,the Second Hospital of Shanxi Medical University,Taiyuan 030001,China)
出处
《中华内分泌外科杂志》
CAS
2023年第2期162-165,共4页
Chinese Journal of Endocrine Surgery
基金
山西省重点研发计划项目(201803D31118)。
关键词
性激素
癌胚抗原
乳腺癌
淋巴结转移
Sex hormone
Carcinoembryonic antigen
Breast cancer
Lymph node metastasis
