摘要
目的:观察鼻渊通窍颗粒联合糠酸莫米松鼻喷剂治疗变应性鼻炎的临床疗效。方法:选择80例变应性鼻炎患者,按随机数字表法分为对照组和观察组各40例。对照组接受糠酸莫米松鼻喷剂治疗,观察组在对照组基础上给予鼻渊通窍颗粒治疗。比较2组治疗前后临床症状评分、血清干扰素-γ(IFN-γ)和白细胞介素-4(IL-4)水平的变化,以及鼻结膜炎相关生活质量问卷(RQLQ)评分的变化。结果:治疗后,2组喷嚏、鼻塞、鼻痒及流涕症状评分较治疗前降低(P<0.05),且观察组各项评分低于对照组(P<0.05)。治疗后,2组血清IL-4水平较治疗前降低,血清IFN-γ水平较治疗前升高(P<0.05),且观察组血清IL-4水平低于对照组,血清IFN-γ水平高于对照组(P<0.05)。治疗后,2组RQLQ量表评分较治疗前降低(P<0.05),且观察组RQLQ量表评分低于对照组(P<0.05)。结论:鼻渊通窍颗粒联合糠酸莫米松鼻喷剂治疗变应性鼻炎可以有效调节血清炎症因子水平,促进临床症状的缓解,提高患者的生活质量。
Objective:To observe the clinical effect of Biyuan Tongqiao Granules combined with Mometasone Furoate Nasal Spray for allergic rhinitis.Methods:A total of 80 cases of patients with allergic rhinitis were selected and divided into the control group and the observation group according to the random number table method,with 40 cases in each group.The control group was treated with Mometasone Furoate Nasal Spray,and the observation group was additionally treated with Biyuan Tongqiao Granules based on the treatment of the control group.The changes in scores of clinical symptoms,levels of interferon-γ(IFN-γ)and interleukin-4(IL-4)in serum,and scores of Rhinoconjunctivitis Quality of Life Questionnaire(RQLQ)were compared between the two groups before and after treatment.Results:After treatment,the scores of symptoms including sneezing,nasal congestion,nasal itching and runny nose in the two groups were decreased when compared with those before treatment(P<0.05),and the above scores in the observation group were lower than those in the control group(P<0.05).After treatment,the levels of serum IL-4 in the two groups were decreased when compared with those before treatment,and the levels of serum IFN-γwere increased when compared with those before treatment(P<0.05);the level of serum IL-4 in the observation group was lower than that in the control group,and the level of serum IFN-γwas higher than that in the control group(P<0.05).After treatment,RQLQ scores in the two groups were decreased when compared with those before treatment(P<0.05),and RQLQ score in the observation group was lower than that in the control group(P<0.05).Conclusion:Biyuan Tongqiao Granules combined with Mometasone Furoate Nasal Spray for allergic rhinitis can effectively regulate the levels of serum inflammatory factors,promote the relief of clinical symptoms,and improve the quality of life of patients.
作者
曲同飞
周国丽
QU Tongfei;ZHOU Guoli
出处
《新中医》
CAS
2023年第7期147-150,共4页
New Chinese Medicine
关键词
变应性鼻炎
鼻渊通窍颗粒
糠酸莫米松
免疫功能
生活质量
炎症因子
Allergic rhinitis
Biyuan Tongqiao Granules
Mometasone Furoate
Immune function
Quality of life
Inflammatory factors
