摘要
变应性鼻炎(allergic rhinitis,AR)是一种常见的上呼吸道慢性炎性疾病,临床表现为喷嚏、清水样涕、鼻塞及鼻痒等症状。AR是全球最常见的过敏性疾病之一,根据有关流行病学调查推算,AR影响着10%~40%的世界人口,我国成人AR患病率为17.6%,并在最近6年显著增加,严重影响患者的健康和生活质量,同时也造成了沉重的医疗和社会负担[1-2]。
The pathogenesis of allergic rhinitis(AR)has not well been clarified,and the imbalance of immune system is its important feature.Interaction between innate and adaptive immune cells and inflammatory mediators secreted by them triggers,maintains and aggravates AR.In this review,Toll-like receptor signaling pathways are used as a bridge to systematically analyze the mechanisms of innate and adaptive immunity in the development of AR.
作者
邱昌余
崔欣燕
程雷
QIU Changyu;CUI Xinyan;CHENG Lei
出处
《临床耳鼻咽喉头颈外科杂志》
CAS
北大核心
2019年第1期28-35,共8页
Journal of Clinical Otorhinolaryngology Head And Neck Surgery
基金
国家自然科学基金(No:81600789)
江苏省基础研究计划-自然科学基金(No:BK20161058)
江苏高校优势学科建设工程(No:JX10231801)
