摘要
子宫内膜容受性和蜕膜化作为胚胎附植的重要环节,影响哺乳动物的成功妊娠和繁殖性能,所以探究子宫生理功能的调控机制对提高母畜繁殖率具有重要意义。子宫内膜容受性是指子宫内膜允许囊胚定位、黏附、侵入并最终着床的能力。为了转变为接受状态,子宫内膜需要经历一系列形态和功能重塑,其中子宫内膜基质细胞会增殖分化为蜕膜细胞,发生蜕膜化过程。非编码RNA(ncRNAs)影响多种生理过程,包括对子宫内膜功能的调节,其中lncRNA-miRNA-mRNA和circRNA-miRNA-mRNA的竞争内源性RNA(ceRNA)网络理论是一种重要的分子调控机制。本文就miRNA、lncRNA和circRNA调控子宫内膜容受性和蜕膜化过程作用机制的研究现状进行综述,以期为深入了解ncRNAs在哺乳动物子宫中的调控作用提供理论指导和新思路。
Endometrial receptivity and decidualization are crucial parts of embryo implantation,which influenced the successful pregnancy and reproductive performance of mammalian.Therefore,it is of great significance to explore the regulatory mechanism of uterine physiological function to improve reproduction efficiency of female animals.Endometrial receptivity is an ability of the endometrium to allow blastocysts to localize,adhere,invade,and eventually implant.To transit into receptive state,the endometrium needs to undergo a series morphologically and functionally remodeling,during which endometrial stromal cells proliferate and differentiate into decidual cells,the process is called decidualization.Non-coding RNAs(ncRNAs)can affect a variety of physiological processes,including involvement in the regulation of endometrial function,and ceRNA network theories of lncRNA-miRNA-mRNA and circRNA-miRNA-mRNA are also important molecular mechanisms.In this review,the current research progresses of miRNA,lncRNA and circRNA in regulating mechanism of endometrial receptivity and decidualization were discussed,with a view to provide theoretical guidance and new ideas for further revealing mechanism of ncRNAs on the physiological function of mammalian uterus.
作者
秦雪
沙懿文
杨梦豪
蔡瑞
庞卫军
QIN Xue;SHA Yiwen;YANG Menghao;CAI Rui;PANG Weijun(Key Laboratory of Animal Genetics,Breeding and Reproduction of Shaanxi Province,College of Animal Science and Technology,Northwest A&F University,Yangling 712100,China)
出处
《畜牧兽医学报》
CAS
CSCD
北大核心
2023年第4期1347-1358,共12页
ACTA VETERINARIA ET ZOOTECHNICA SINICA
基金
国家生猪产业技术体系(CARS-35)
国家重点研发计划课题(2021YFF1000602)
陕西省重点研发计划项目(2022ZDLNY01-04)。
