摘要
目的 探讨消炎利胆片对胆囊结石内镜保胆取石术后疗效、炎性因子及结石复发的影响。方法 选择2021年1-12月本院收治的120例胆囊结石患者作为研究对象,随机分为研究组与对照组两组,每组各60例。对照组采取内镜下保胆取石术治疗,研究组在此基础上予以消炎利胆片治疗。比较两组临床疗效及结石复发率;比较两组术后排气时间、排便时间及抗菌药物应用时间;比较两组治疗前后空腹胆囊壁厚度、胆囊排空率、间接胆红素、总胆汁酸、白介素-6(IL-6)及肿瘤坏死因子-α(TNF-α)水平。结果 研究组患者总有效率与对照组比较升高(P<0.05)。研究组患者术后排气时间、排便时间及抗菌药物应用时间少于对照组(P<0.05)。两组患者治疗后胆囊排空率高于治疗前(P<0.05),研究组患者治疗后胆囊排空率高于对照组(P<0.05)。两组患者治疗后空腹胆囊壁厚度、间接胆红素、总胆汁酸、IL-6及TNF-α水平少于治疗前(P<0.05),研究组患者治疗后空腹胆囊壁厚度、间接胆红素、总胆汁酸、IL-6及TNF-α水平显著少于对照组(P<0.05)。为期6个月年随访,研究组患者胆囊结石复发率较对照组明显减少(P<0.05)。结论 消炎利胆片有助于提高胆囊结石内镜保胆取石术后疗效,减轻炎性因子及减少结石复发。
Objective To investigate the effect of Xiaoyan Lidan Tablet on the efficacy,inflammatory factors and recurrence of cholecystolithiasis after endoscopic choledocholithotomy.Methods A total of 120 patients suffered from cholecystolithiasis those were admitted to our hospital from January 2021 to December 2021 were enrolled as study subjects and they were randomly divided into study group and control group,with 60 patients in each group.Patients in the control group was treated with choledocholithotomy under endoscope,and the study group was treated with Xiaoyan Lidan Tablet on this basis.The clinical efficacy and stone recurrence rate of the two groups were evaluated.The postoperative exhaust time,defecation time and antibacterial drug application time were compared between the two groups.The fasting gallbladder wall thickness,gallbladder emptance rate,indirect bilirubin,total bile acid,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were compared between the two groups before and after treatment.Results The total effective rate in the study group was significantly higher than that in the control group(P<0.05).The time of exhaust,defecation and antibacterial drug application in the study group were significantly shorter than those in the control group(P<0.05).The gallbladder emptying rate of patients in the two groups after treatment was significantly higher than that before treatment(P<0.05),and the gallbladder emptying rate of patients in the study group after treatment was significantly higher than that in the control group(P<0.05).After treatment,fasting gallbladder wall thickness,indirect bilirubin,total bile acid,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels were lower than those before treatment(P<0.05),and fasting gallbladder wall thickness,indirect bilirubin,total bile acid,interleukin-6(IL-6)and tumor necrosis factor-α(TNF-α)levels in the study group after treatment were lower than those in the control group(P<0.05).During 6-month follow-up,the recurrence rate of gallstone
作者
张新亮
卢慧莹
马卫中
Zhang Xinliang;Lu Huiying;Ma Weizhong(Department of general surgeryHenan provincial disabled soldier hospital,Xinxiang,Henan,453000,China;thoracic surgery department,Henan provincial disabled soldier hospital,Xinxiang,Henan,453000,China)
出处
《齐齐哈尔医学院学报》
2023年第7期640-643,共4页
Journal of Qiqihar Medical University
关键词
消炎利胆片
胆囊结石
内镜保胆取石
炎性因子
结石复发
Xiaoyan Lidan Tablets
Gallstone
Endoscopic choledocholithotomy
Inflammatory factors
Stone recurrence
