摘要
糖苷酶可水解含糖化合物的糖苷键,在细胞代谢和病毒识别中发挥着重要作用。糖苷酶异常与多种疾病相关,如病毒感染、糖尿病、溶酶体贮积症和癌症等。糖苷酶抑制剂可调控糖苷酶活性,用于疾病治疗。现已从植物和微生物中分离出上百种糖苷酶抑制剂,其中α-葡糖苷酶抑制剂阿卡波糖、葡糖神经酰胺合成酶抑制剂麦格司他等已应用于临床。此外,糖苷酶在一些疾病中表达下调或缺失,其激活剂的研发也值得重视。
Glycosidases hydrolyze the glycosidic bonds of sugar-containing compounds and play an important role in cellular metabolism and virus recognition.A variety of diseases were caused by glycosidase abnormalities,such as viral infections,diabetes,lysosomal storage disorders and cancers.Glycosidase activity can be regulated by glycosidase inhibitors in vivo to achieve clinical treatment.Hundreds of glycosidase inhibitors have been isolated from plants and microorganisms,among whichα-glucosidase inhibitor acarbose and glucosylceramide synthase inhibitor miglustat have been used for clinical treatment.In addition,the expression of glycosidases is downregulated or absent in some diseases,and the research of their activators are also worthy of attention.
作者
刘瑞杰
陈妍雯
袁舒颖
张绍兴
芦鑫荣
孔维溧
陈力
孙桂芹
LIU Rui-jie;CHEN Yan-wen;YUAN Shu-ying;ZHANG Shao-xing;LU Xin-rong;KONG Wei-li;CHEN Li;SUN Gui-qin(School of Medical Technology and Information Engineering,Zhejiang Chinese Medical University,Hangzhou ZHEJIANG 310053,China;Department of Medical Microbiology and Parasitology,Key Laboratory of Medical Molecular Virology of Ministries of Education and National Health Committee,School of Basic Medical Sciences,Fudan University,SHANGHAI 200032,China)
出处
《中国新药与临床杂志》
CAS
CSCD
北大核心
2023年第3期145-152,共8页
Chinese Journal of New Drugs and Clinical Remedies
基金
浙江省自然科学基金(LY20C050002)
浙江中医药大学校级科研基金(2020ZG25)
浙江省大学生科技创新活动计划暨新苗人才计划(2021R410051)。
关键词
糖苷酶
糖苷水解酶抑制剂
药理作用机制
糖尿病
癌
治疗
glycosidases
glycoside hydrolase inhibitors
pharmacological mechanisms of action
diabetes mellitus
carcinoma
therapy
