摘要
检测样本中游离及共价连接在糖肽上的寡糖链,构成糖谱。糖谱上寡糖链类型和丰度的变化可能与病理生理改变相关,具重要的诊断价值,并已应用于临床检测。综述糖谱在肿瘤、感染性疾病、自身免疫性疾病、遗传性疾病中的变化,以及糖谱分析在体外诊断中的进展,为糖谱检测的临床应用提供方向。
Glycan profile is a collective presentation of free and conjugated oligosaccharides detected in a clinical sample.The changes of glycan profile,which might reflect physiological and pathological changes,have diagnostic value,and have been applied in various clinical settings.This paper reviews the current applications of glycan profile in tumors,infections,autoimmune conditions and genetic diseases,as well as the new development of glycan profiling methods,aiming to provide some new insights for the clinical application of glycan profile based detection.
作者
孙桂芹
陈妍雯
张绍兴
刘瑞杰
张瑜芯
芦鑫荣
童永亮
陈力
陈萃英
SUN Guiqin;CHEN Yanwen;ZHANG Shaoxing;LIU Ruijie;ZHANG Yuxin;LU Xinrong;TONG Yongliang;CHEN Li;CHEN Cuiying(School of Medical Technology and Information Engineering,Zhejiang Chinese Medical University,Hangzhou 310053,China;Ministry of Education/National Health Commission/Chinese Academy of Medical Sciences Key Laboratory of Medical Molecular Virology,Department of Medical Microbiology and Parasitology,Fudan University,Shanghai 200032,China;Sysdiagno Biomedtech Co.,Ltd.,Nanjing211800,China)
出处
《药学进展》
CAS
2023年第6期424-432,共9页
Progress in Pharmaceutical Sciences
基金
浙江中医药大学-先思达生物科技有限公司合作项目(No.2023-HT-275)。
关键词
糖基化
糖谱
疾病
体外诊断
临床应用
glycosylation
glycan profile
disease
in vitro diagnostic
clinical application
