摘要
Damaged skin cannot prevent harmful bacteria from invading tissues,causing infected wounds or even severe tissue damage.In this study,we developed a controlled-release antibacterial composite hydrogel system that can promote wound angiogenesis and inhibit inflammation by sustained releasing Cu-Epigallocatechin-3-gallate(Cu-EGCG)nano-capsules.The prepared SilMA/HAMA/Cu-EGCG hydrogel showed an obvious inhibitory effect on Escherichia coli(E.coli)and Staphylococcus aureus(S.aureus).It could also promote the proliferation and migration of L929 fibroblasts.In vivo full-thickness infected wound healing experiments confirmed the angiogenesis and inflammation regulating effect.Accelerate collagen deposition and wound healing speed were also observed in the SilMA/HAMA/Cu-EGCG hydrogel treated group.The findings of this study show the great potential of this controlled-release antibacterial composite hydrogel in the application of chronic wound healing.
基金
funded by National Key Research and Development Program of China(2017YFA0105602,2018YFA0108700)
NSFC Projects of INTERNATIONAL COOPERATION and Exchanges(81720108004)
National Natural Science Foundation of China(81974019,82100275)
Guangdong Provincial Special Support Program for Prominent Talents(2021JC06Y656)
Science and Technology Planning Project of Guangdong Province(2020B1111170011,2022B1212010010)
Guangdong special funds for science and technology innovation strategy,China(Stability support for scientific research institutions affiliated to Guangdong Province-GDCI 2021)
Guangzhou Science and Technology Plan Project(202201000006)
The Special Project of Dengfeng Program of Guangdong Provincial People’s Hospital(DFJH201812,KJ012019119,KJ012019423)
The Marine Economy Development Project of Department of Natural Resources of Guangdong Province(No.GDNRC[2022]039).
