摘要
目的借助数据挖掘技术,探讨电针及经颅电刺激治疗痴呆的刺激参数应用规律。方法检索中国知网(CNKI)、维普中文期刊服务平台(VIP)、万方数据知识服务平台(WanFang Data)、中国生物医学文献服务平台(CBM)、PubMed、Web of Science、Embase、Cochrane Library、Medline等中英文数据库中电针及经颅电刺激治疗痴呆的临床研究文献,文献发表时间为建库至2022年5月。采用Cochrane 5.4偏倚风险评估工具对纳入文献中的随机对照试验进行质量评价。建立电刺激参数数据库,并采用描述性分析、关联规则分析及聚类分析进行数据挖掘。结果(1)最终纳入文献175篇,其中143篇为随机对照试验,包含数据179组。(2)总体而言,电针及经颅电刺激治疗痴呆时,常用的脉冲波形为连续波(57次,50.44%)和疏密波(44次,38.94%),电刺激频率为300~500次/min(即5.00~8.33 Hz)。电针疗法电刺激强度常以患者耐受为度,单次治疗时间以30 min多见;经颅电刺激疗法电刺激强度则多为2 mA,单次治疗时间常选择20 min。(3)电针及经颅电刺激治疗血管性痴呆(VaD)时,常用的刺激参数与文献总体情况一致。治疗阿尔茨海默病(AD)时的刺激参数则有所差异:常用的脉冲波形为连续波,电刺激频率为10/50 Hz,电针疗法电刺激强度常以患者耐受为度,经颅电刺激疗法电刺激强度则多为2 mA,在单次治疗时间的选择方面,电针及经颅电刺激均常选择30 min。(4)电刺激选用频次最多的腧穴为百会、四神聪、风池、神庭、本神,经穴归属频次最高的经脉为督脉、胆经及胃经。(5)关联规则分析结果显示,电针治疗痴呆最常用的双穴配伍为百会-神庭,3穴配伍为四神聪-风池-百会,4穴配伍为百会-神庭-风池-四神聪;聚类分析亦发现,常用穴位所形成的聚类群中,风池与四神聪、百会与神庭各占一类。结论电针及经颅电刺激治疗痴呆时常选用连续波,频率为300~500次/min(�
Objective To study the application rules of stimulation parameters of electroacupuncture and transcranial electrical stimulation(TES)for dementia with data mining techniques.Methods Both Chinese databases including Chinese National Knowledge Infrastructure(CNKI),VIP Database for Chinese Technical Periodicals(VIP),WanFang Data,China Biology Medicine(CBM)and English databases including PubMed,Web of Science,Embase,and Cochrane Library were systematically searched for clinical research literature related to electroacupuncture and TES for dementia which were published from the establishment of databases up to May 2022.The quality of randomized controlled trials in the included literature was assessed using the Cochrane 5.4 risk of bias tool.A database of electrical stimulation parameters was established and data mined using descriptive analysis,association rules,and cluster analysis.Results①Finally,175 articles were included,of which 143 were randomized controlled trials,containing data from 179 groups.②Overall,the frequently used pulse waveforms were continuous wave(57 times,50.44%)and disperse-dense wave(44 times,38.94%),and electrical stimulation frequency was 300 to 500 times/min(5.00-8.33 Hz)when using electroacupuncture and TES for dementia.The electrical stimulation intensity of electroacupuncture therapy was often determined by patient tolerance,and a single treatment session was 30 min.The stimulation intensity of TES therapy was 2 mA,and a single treatment session was 20 min.③The commonly used stimulation parameters of electroacupuncture and TES for vascular dementia(VaD)were consistent with literature data in general,while those for Alzheimer’s disease(AD)were different from literature data:the frequently used pulse waveform was continuous wave,and the electrical stimulation frequency was 10/50 Hz.The electrical stimulation intensity was determined by patient tolerance for electroacupuncture,while that of TES was 2 mA,and a single treatment session often lasted 30 min for both electroacupuncture an
作者
郭亭廷
嵇波
刘翼天
方洋
葛云鹏
谢亚娜
韩娜娜
张玲
王一菲
吴乐
GUO Tingting;JI Bo;LIU Yitian;FANG Yang;GE Yunpeng;XIE Yana;HAN Nana;ZHANG Ling;WANG Yifei;WU Le(School of Acupuncture-Moxibustion and Tuina,Beijing University of Chinese Medicine,Beijing 100029,China)
出处
《上海中医药杂志》
CSCD
2023年第4期65-71,共7页
Shanghai Journal of Traditional Chinese Medicine
基金
国家自然科学基金项目(82174505)。
关键词
痴呆
阿尔茨海默病
电针
经颅电刺激
刺激参数
中医药疗法
dementia
Alzheimer’s disease
electroacupuncture
transcranial electrical stimulation
stimulation parameter
traditional Chinese medicine therapy
