摘要
目的探讨38例白塞病大血管病变患者临床特征与危险因素。方法回顾性分析郑州大学第一附属医院2017年1月至2022年3月收治的410例白塞病患者临床资料,根据患者有无大血管病变分为大血管病变组(38例)和无大血管病变组(372例),比较两组患者的流行病学特征(性别、年龄等)、临床表现(口腔溃疡、外阴溃疡、葡萄膜炎、肠白塞、脑白塞、结节红斑、针刺反应、关节受累等)、实验室检查结果等资料。分析影响白塞病大血管病变的危险因素。结果大血管病变组男性、外阴溃疡比例高于无大血管病变组,差异有统计学意义(P<0.05);大血管病变组白细胞计数、中性粒细胞计数、C反应蛋白、D二聚体水平高于无大血管病变组,差异有统计学意义(P<0.05);Logistic回归分析结果显示,性别、甘油三酯、D二聚体是白塞病大血管病变的危险因素,差异有统计学意义(P<0.05)。结论性别、甘油三酯、D二聚体均是白塞病大血管病变的危险因素。
Objective To explore the clinical characteristics and risk factors of 38 patients with large vessel lesions in Behcet's disease.Methods A retrospective analysis was conducted on the clinical data of 410 patients with Behcet's disease admitted to the First Affiliated Hospital of Zhengzhou University from January 2017 to March 2022.They were divided into two groups based on the presence or absence of large vessel lesions:the large vessel lesion group(38 cases)and the non-large vessel lesion group(372 cases).The epidemiological characteristics(gender,age,etc.),clinical manifestations(oral ulcers,vulvar ulcers,uveitis,intestinal congestion,cerebral congestion,nodular erythema,acupuncture reactions,joint involvement,etc.),laboratory examination results,and other information of the two groups of patients were compared,the risk factors affecting macrovascular lesions in Behcet's disease were analyzed.Results The proportion of male and vulvar ulcers in the large vessel lesion group was higher than that in the non-large vessel lesion group,and the difference was statistically significant(P<0.05);The white blood cell count,neutrophil count,C-reactive protein,and D-dimer levels in the large vessel lesion group were higher than those in the non-large vessel lesion group,with statistically significant differences(P<0.05);The results of logistic regression analysis showed that gender,triglycerides,and D-dimer were risk factors for macrovascular lesions in Behcet's disease,with statistically significant differences(P<0.05).Conclusion Gender,triglycerides,and D-dimer are all risk factors for macrovascular lesions in Behcet's disease.
作者
苏瑶瑶
刘升云
SU Yaoyao;LIU Shengyun(Department of Rheumatology and Immunology,First Affiliated Hospital of Zhengzhou University,Zhengzhou Henan 450000,China)
出处
《临床研究》
2023年第5期4-7,共4页
Clinical Research
关键词
白塞病大血管病变
血管系统损伤
心脏病变
临床特征
危险因素
Behcet's disease with macrovascular lesions
vascular system damage
cardiac disease
clinical characteristics
risk factors
