摘要
目的运动训练已被证明能够改善许多慢性肌肉功能疾病,被用于治疗衰老型肌萎缩。本文采用电阻抗成像(electrical impedance tomography,EIT)研究人类小腿肌肉对运动训练生理响应的电学特性,旨在使用EIT方法可视化运动训练对人类小腿响应肌肉隔室内肌肉纤维体积增加的效果。方法实验对象被要求在连续5个实验日进行左、右腿单侧提踵训练,应用EIT检测每日运动训练前和运动训练后小腿肌肉的电导率分布。为了定量分析运动训练对响应肌肉隔室的作用,使用配对样本t检验分析EIT重建图像的空间平均电导率<σ>。结果运动训练后,由小腿腓肠肌组成的M_(1)肌肉隔室空间平均电导率<σ>_(M1)显著增加。此外,连续5个实验日的EIT测量结果显示,运动训练前的空间平均电导率<σ^(pre)>_(M1)呈上升趋势。所有实验对象在实验日1早晨进行实验前的腿部瘦体重与<σ>_(M1)呈线性关系,即<σ>_(M1)随腿部瘦体重增加而增加;运动训练前和训练后腿部M_(1)肌肉隔室空间平均电导率及空间平均电导率差比的增长趋势与细胞外液体积差比率相同。结论由于电导率对细胞外水分量变化敏感,而细胞外液体积变化与肌浆肥大相关。在连续5 d的EIT测量中,空间平均电导率<σ^(pre)>_(M1)呈上升趋势,这意味着肌肉纤维体积的增加,发生肌浆肥大现象。因此,EIT能够有效地评估运动训练增加人类小腿肌肉纤维体积的效果。
Objective Locomotor training has been shown to preferentially affect muscle function in many chronic diseases which has been used in the treatment of sarcopenia.In this study,we propose electrical impedance tomography(EIT)to study the electrical characteristics of physiological response in calf muscle compartments induced by locomotor training,which is intended to visualize the effectiveness of locomotor training on the increase in volume of calf muscle fibers.Methods Experimental subjects were asked to perform unilateral heel rises on the right and left legs on 5 consecutive experimental days.EIT was applied to detect the conductivity distribution of calf muscles after locomotor training.In order to quantify the effectiveness of locomotor training,a paired sample t-test was used to analyze the spatial-mean conductivity<σ>from reconstructed EIT images.Results The results show that the spatial-mean conductivity<σ>_(M1)of M_(1)compartment(which is recognized as the position of the gastrocnemius muscle)is significantly increased in post-training by locomotor training.In addition,the spatial-mean conductivity in pre-training<σ^(pre)>_(M1)shows an increasing tendency in EIT measurement results on 5 consecutive experimental days.The lean mass of all subjects in pre-and post-training parts which was performed in the morning of experimental day 1 is linearly related to<σ>_(M1);the increase in<σ>_(M1)and spatial-mean conductivity difference ratioΔ<σ>_(M1)between pre-and post-training followed the same tendency as extracellular water/intracellular water(ECW/ICW)r by ECW/ICW difference ratioΔτ.Conclusion Since conductivity is sensitive to changes in extracellular volume which correlates with sarcoplasmic hypertrophy.The<σ^(pre)>_(M1)tended to increase during 5 consecutive experimental days of EIT measurements,which implies an increase in muscle fiber volume with sarcoplasmic hypertrophy occurring.Therefore,EIT is able to effectively detect the effectiveness of locomotor training to increase the volume of human cal
作者
孙博
Prima Asmara Sejati
姚佳烽
SUN Bo;Prima Asmara Sejati;YAO Jia-Feng(School of Mechanical and Precision Intrument Engineering,Xi’an University of Technology,Xi’an 710048,China;Department of Mechanical Engineering,Chiba University,Chiba 263-0022,Japan;Department of Electrical Engineering and Informatics,Vocational College,Universitas Gadjah Mada,Yogyakarta 55281,Indonesia;College of Mechanical&Electrical Engineering,Nanjing University of Aeronautics&Astronautics,Nanjing 210016,China)
出处
《生物化学与生物物理进展》
SCIE
CAS
CSCD
北大核心
2023年第3期595-605,共11页
Progress In Biochemistry and Biophysics
基金
国家自然科学基金(62071224)资助项目。
关键词
电阻抗成像
运动训练
生理性响应
肌肉组织细胞外液体积
肌肉纤维体积
肌浆肥大
electrical impedance tomography(EIT)
locomotor training
physiological response
muscle extracellular volume
muscle fiber volume
sarcoplasmic hypertrophy
