摘要
温度是人体的重要机能,血液温度变化监测对人体健康评估尤为重要。本文提出拓展的浓厚分散系HANAI理论,结合生物电阻抗谱,量化表征温度对血液生物电阻抗特性的影响规律,为监测血液温度及相关血液疾病的演变过程提供基础。试验结果表明,随着温度T不断上升,血液的生物电阻抗参数Z^(+)持续下降;奈奎斯特峰值电阻参数R_(c)和峰值电抗参数X_(c)与温度T有良好的线性关系,可描述为R_(c)=-0.3T+24.14和X_(c)=0.08T-5.78。将传统HANAI方程进行拓展,并进行多物理场数值模拟,其数值分析、模拟结果与试验结果较好吻合,揭示了血浆电导率σ_(p)和细胞质电导率σ_(p)是温度对血液生物电阻抗特性的主要影响因素。本文展示了一种潜在的血液温度监测方法,在临床医学领域或有一定的科研与应用价值。
Temperature is the important function that affects the normal function of human body.Blood temperature change monitoring is particularly important for the assessment of human health.Based on the proposed extended HANAI theory of the dense dispersion system,the influence of temperature on the impedance characteristics of blood has been quantitatively evaluated by bioelectrical impedance spectroscopy measurement,which provides a feasible quantitative characterization basis for blood temperature and related blood disease monitoring.Experimental results show that,under the condition that the temperature T increases,the impedance Z^(+) decreases continuously.It founds that the resistance R_(c)and reactance X_(c)have great linear relationship with the temperature T,which could be described as R_(c)=-0.3T+24.14 and X_(c)=0.08T-5.78,respectively.The tranditional HANAI equation for dense solution is extended.The numerical analysis and simulation results show great agreement with experimental results which confirm the fact that the conductivitiesσ_(p)of plasma and the conductivitiesσ_(p)of cytoplasm are responsible for the influence of temperature on blood impedance characteristics.This study indicates a potential non-invasive temperature measurement method for blood or other solutions,which has certain scientific research and application value.
作者
李建平
何立栋
万嫩
温建明
杨宇祥
Li Jianping;He Lidong;Wan Nen;Wen Jianming;Yang Yuxiang(College of Engineering,Zhejiang Normal University,Jinhua 321004,China;College of Engineering and Design,Hunan Normal University,Changsha 410081,China)
出处
《仪器仪表学报》
EI
CAS
CSCD
北大核心
2021年第9期236-243,共8页
Chinese Journal of Scientific Instrument
基金
浙江省自然科学基金(LY19E050010)
浙江省北航创新研究院钱江实验室开放基金(2020-Y1-A-028)项目资助。
关键词
HANAI方程
生物电阻抗谱
血液
温度
传感
HANAI equation
bioelectrical impedance spectroscopy
blood
temperature
sensing
