摘要
目的探讨扩散峰度成像(DKI)对鼻咽癌局部复发和放射性炎症/纤维化等的鉴别诊断价值。方法收集鼻咽癌放化疗后定期复查临床怀疑复发或磁共振检查异常信号的患者30例,根据鼻咽镜检查病理结果,部分未取到病理的以PET-CT为准,分为鼻咽癌复发组和放射性炎症/纤维化组,行磁共振检查DKI序列测得DKI参数,包括平均扩散系数(MD),平均扩散峰度(MK),各向异性分数(FA),对组间差异进行统计学分析,绘制ROC曲线图并计算出曲线下面积。结果鼻咽癌复发组与放射性炎症/纤维化组DKI参数对比组间差异,MD和MK值对比具有统计学意义(P<0.05),FA值对比差异无统计学意义(P>0.05)。MD、MK评价鼻咽癌复发的曲线下面积分别为0.891、0.806。结论本研究认为DKI定量参数在鼻咽癌复发鉴别诊断有重要价值,其中参数MD、MK具有较好的敏感性和特异性。
Objective To investigate the value of diffusion kurtosis imaging(DKI)in the differential diagnosis of locally recurrent nasopharyngeal carcinoma and radiation inflammation/fibrosis.Methods A total thirty patients with nasopharyngeal carcinoma who were suspected of recurrence or abnormal signals of magnetic resonance imaging(MRI)were collected after radiotherapy and chemotherapy.These cases were divided into local recurrent nasopharyngeal carcinoma group and radiation inflammation/fibrosis group based on nasopharyngeal biopsy and PET-CT.The quantitative parameters of DKI were measured,such as mean diffusivity(MD),mean kurtosis(MK),fractional anisotropy(FA).The differences between groups were statistically analyzed.Finally,we draw ROC curve and calculate the area under the curve.Results There was significant difference in DKI parameters between recurrent nasopharyngeal carcinoma group and radiation inflammation/fibrosis group(P<0.05),and there was no significant difference in FA values(P>0.05).The area under the curve of MD and MK was 0.891 and 0.806 respectively.Conclusion This study suggests that the quantitative parameters of DKI have important value in the differential diagnosis of recurrent nasopharyngeal carcinoma.The parameters MD and MK have good sensitivity and specificity.
作者
刘萌
郑德春
岳秋圆
沈芳敏
何庄贞
LIU Meng;ZHENG De-chun;YUE Qiu-yuan;SHEN Fang-min;HE Zhuang-zhen(Department of Radiotherapy,Clinical Oncology School of Fujian Medical University/Fujian Cancer Hospital,Fuzhou 350012,Fujian Province,China)
出处
《罕少疾病杂志》
2023年第4期30-31,52,共3页
Journal of Rare and Uncommon Diseases
基金
福建省卫生计生科研人才培养项目青年科研课题(2018-2-6)。
关键词
鼻咽癌复发
扩散峰度成像
放射性炎症
放射性纤维化
Recurrent Nasopharyngeal Carcinoma
Diffusion Kurtosis Imaging
Radiation Inflammation
Radiation Fibrosis
