摘要
目的探讨利托君与硝苯地平联合硫酸镁在先兆早产治疗中的临床疗效。方法选取80例先兆早产患者,按照随机数字表法分为两组。对照组(40例)采用硫酸镁进行治疗,试验组(40例)在对照组基础上加用利托君联合硝苯地平进行治疗。对比两组临床疗效、炎症因子、妊娠结局及不良反应发生情况。结果试验组临床总有效率95.00%高于对照组的80.00%(P<0.05)。试验组治疗后促肾上腺皮质释放激素(CRH)、C反应蛋白(CRP)、肿瘤坏死因子-α(TNF-α)及白细胞介素-6(IL-6)水平均低于对照组(P<0.05)。试验组分娩孕周长于对照组,宫缩消失时间短于对照组,新生儿评分高于对照组(P<0.05)。两组不良反应发生率对比,差异无统计学意义(P>0.05)。结论利托君与硝苯地平联合硫酸镁在先兆早产患者中疗效显著,能够有效降低CRH及炎症因子水平,有助于改善妊娠结局,且不会增加不良反应发生率,具有较高安全性。
Objective To investigate the clinical effect of Ritodrine and nifedipine combined with magnesium sulfate in the treatment of threatened premature labor.Methods 80 patients with threatened preterm labor were selected and divided into two groups according to random number table method.The control group(40 cases)was treated with magnesium sulfate,and the experimental group(40 cases)was additionally treated with Ritodrine and nifedipine.The clinical efficacy,inflammatory factors,pregnancy outcome and the occurrence of adverse reactions were compared between the two groups.Results The total clinical effective rate of experimental group was 95.00%higher than that of control group 80.00%(P<0.05).The levels of corticotropin-releasing hormone(CRH),C-reactive protein(CRP),tumor necrosis factor-α(TNF-α)and interleukin-6(IL-6)in experimental groups were lower than those in control group after treatment(P<0.05).The gestational circumference of the experimental group was shorter than that of the control group,the disappearance time of contractions was shorter,and the neonatal score was higher than that of the control group(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion Ritodrine and nifedipine combined with magnesium sulfate have significant efficacy in patients with threatened premature delivery,which can effectively reduce the levels of CRH and inflammatory factors,help to improve pregnancy outcome,and does not increase the incidence of adverse reactions,with high safety.
作者
刘慧娜
Liu Huina(Department of Obstetrics and Gynecology,Affiliated Hospital of Gansu Medical College,Pingliang 744000,China)
出处
《实用妇科内分泌电子杂志》
2022年第31期40-43,共4页
Electronic Journal of Practical Gynecological Endocrinology
关键词
先兆早产
利托君
硝苯地平
硫酸镁
临床疗效
妊娠结局
Threatened premature delivery
Ritodrine
Nifedipine
Magnesium sulfate
Clinical effect
Pregnancy outcome
