摘要
目的分析低剂量阿司匹林(LDA)联合硫酸镁治疗子痫前期(PE)的效果.方法选择2020年2月—2022年2月本院收治的68例PE患者,按随机数字表法分为两组.对照组(n=34)采用硫酸镁注射剂治疗,观察组(n=34)在此基础上采用LDA治疗,两组均持续治疗至终止妊娠前1周.对比两组患者的临床疗效、舒张压、收缩压、24 h尿蛋白、凝血功能、子宫动脉血流指数及不良反应发生率.结果治疗后,观察组的临床总有效率为97.06%,高于对照组的76.47%,差异有统计学意义(P<0.05).治疗后,观察组的舒张压、收缩压、24 h尿蛋白均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的部分凝血活酶时间、凝血酶原时间均长于对照组,纤维蛋白原、凝血酶原活动度均低于对照组,组间差异有统计学意义(P<0.05).治疗后,观察组的阻力指数、搏动指数、收缩期最大血流速度/舒张末期血流速度均高于对照组,组间差异有统计学意义(P<0.05).两组的不良反应发生率比较,差异无统计学意义(P>0.05).结论LDA联合硫酸镁治疗PE的效果显著,能有效控制患者血压、24 h尿蛋白,改善其凝血功能及子宫动脉血流,且安全性较好.
Objective To analyze the effect of low-dose aspirin(LDA)combined with magnesium sulfate in patients with preeclampsia(PE).Methods 68 patients with PE admitted to our hospital from February 2020 to February 2022 were selected and were divided into two groups according to random number table method.The control group(n=34)was treated with magnesium sulfate injection,and the observation group(n=34)was treated with LDA on this basis.Both groups continued treatment until 1 week before termination of pregnancy.The clinical efficacy,diastolic blood pressure,systolic blood pressure,24 h urinary protein,coagulation function,uterine artery blood flow index and incidence of adverse reactions were compared between the two groups.Results After treatment,the total clinical effective rate of the observation group was 97.06%,higher than 76.47%of the control group,the difference was statistically significant(P<0.05).After treatment,the diastolic blood pressure,systolic blood pressure and 24 h urinary protein in the observation group were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the activeated partial thrombin time and prothrombin time in the observation group were longer than those in the control group,while the fibrinogen and prothrombin activity were lower than those in the control group,and the differences between the groups were statistically significant(P<0.05).After treatment,the resistance index,pulsation index,systolic maximum blood flow velocity/diastolic end blood flow velocity in the observation group were higher than those in the control group,and the differences between the groups were statistically significant(P<0.05).There was no significant difference in the incidence of adverse reactions between the two groups(P>0.05).Conclusion LDA combined with magnesium sulfate in the treatment of PE has significant effects,which can effectively control blood pressure and 24 h urinary protein,improve coagulation function and uterine arter
作者
李昀筱
施小飞
董娟娟
LI Yunxiao;SHI Xiaofei;DONG Juanjuan(Department of Obstetrics and Gynecology,Lanzhou Second People's Hospital,Lanzhou Gansu,730000,China)
出处
《反射疗法与康复医学》
2023年第1期152-155,共4页
Reflexology And Rehabilitation Medicine
关键词
子痫前期
阿司匹林
硫酸镁
凝血功能
子宫动脉血流
Preeclampsia
Aspirin
Magnesium sulphate
Coagulation function
Uterine artery blood flow
