摘要
环境、生理和病理因素的改变会导致光电容积波(photoplethysmography, PPG)波形的变化。为探究氧含量降低时PPG波形的变化,本研究在氧浓度为13.4%的常压低氧舱中(相当于海拔3 600 m)开展实验,记录每个志愿者在短时低氧暴露之前和过程中的指尖PPG信号,提取了9个与面积和时间特征相关的PPG参数,并测量了4次血压。结果表明,由常氧环境进入低氧环境后,7个PPG参数在所有志愿者中发生了显著一致的变化(P<0.05),2个参数的变化不具显著性差异,且各PPG参数的变化方向不同。从PPG中提取的脉率变异性(pulse rate variation, PRV)指标具有相似的变化规律。当氧含量降低时,PPG面积参数的升高与低氧暴露导致血管外周阻力增加的生理机制相符,PPG时间参数与血压呈负相关。本研究可为低氧条件下无创监测人体外周血管阻力和其他生理指标的变化提供思路,并为缺氧环境中工作人员的健康监测提供参考。
The changes in environmental factors,physiological factors and pathological factors will lead to variations of photoplethysmographic(PPG)waveform.In order to explore the PPG waveform alters from normal oxygen concentration environment to low oxygen level environment,we carried out experiment in a normobaric hypoxic chamber which created an acute low oxygen level condition.The oxygen concentration was set as 13.4%.Fingertip PPG signal was recorded in the whole process and blood pressure(BP)was measured for 4 times.Nine PPG parameters were extracted for each subject before and during they were shortly exposed to hypoxia.The results showed that 7 PPG parameters had significant and consistent changes in all volunteers(P<0.05)after changed place from normal environment to hypoxic chamber.There were not significant changes in 2 parameters.Pulse rate variability(PRV)indicators showed similar regularity,whereas the varying directions of each PPG parameter were not same.From normoxic to hypoxic environment,the raised value of PPG area parameters tallied with the physiological mechanism that hypoxic exposure increased peripheral vascular resistance,and the PPG time parameters were negatively related with the BP.This study can provide ideas for non-invasive monitoring of human peripheral vascular resistance and other physiological indicators under hypoxia conditions,and reference for health monitoring of workers in anoxic environment.
作者
李洋
李建清
颜昌
曹征涛
董珂君
刘澄玉
LI Yang;LI Jianqing;YAN Chang;CAO Zhengtao;DONG Kejun;LIU Chengyu(School of Instrument Science and Engineering,Southeast University,Nanjing 210096,China;Air Force Medical Center,PLA,Aeromedicine Engineering Center,Beijing 100142,China;School of Information Science and Engineering,Southeast University,Nanjing 210096)
出处
《生物医学工程研究》
2023年第1期1-7,共7页
Journal Of Biomedical Engineering Research
基金
国家自然科学基金资助项目(81871444,62171123,62071241)
国家重点研发计划项目(2019YFE0113800)
江苏省自然科学基金资助项目(BK20190014,BK20192004)。
关键词
血压
形态参数
低氧刺激
脉搏特征
变异规律
心脏
特征提取
心血管
Blood pressure
Morphological parameters
Hypoxic stimulation
Pulse features
Variation patterns
Heart
Feature extraction
Cardiovascular
