摘要
目的:评估急诊科中成药的合理用药现状。方法:以“合理用药”OR“处方分析”OR“处方点评”AND“中成药”OR“中药注射剂”OR“注射液”AND“急诊科”进行主题检索,检索中国知网(CNKI)数据库,从建库至2022年8月1日的所有文献,按文献来源、发表年份、作者及机构所属区域、研究人群年龄分布、不合理用药情况等对文献进行分类,应用文献计量学方法评估急诊科中成药的合理用药情况。结果:通过专业检索及手动剔除误纳入的文献,最终纳入急诊科中成药相关的文献121篇,共刊登在65种期刊上。整体上,文献发表数量呈上升趋势,来自华东地区的研究者相对更加关注急诊科中成药的合理用药情况。纳入文献总体处方总数为1160273,不合理处方15815个。其中不适宜处方占比57.53%,不规范处方和超常处方分别占比21.16%和10.79%。儿童(或婴幼儿)急诊科中成药处方总数为32179,不合理处方数量为2211个。其中不规范处方、不适宜处方和超常处方分别占比16.46%,30.48%和50.57%。急诊科儿童不合理用药以清热类和祛痰类中成药为主,不合理用药以超说明书用药为主。急诊科老年人以活血化瘀类中成药为主,不合理用药情况以重复给药和联合用药不适宜为主。中成药不良反应以皮肤和消化系统症状为主,相关的不合理用药情况包括联合用药不适宜、重复用药、注射剂溶媒不适宜(或给药途径或剂型不适宜)。结论:中成药在急诊科合理用药的研究数量有限、质量不高,未来亟须制定急诊科的中成药临床使用指导原则,优化评判标准,为切实推动中成药在急诊科的合理规范应用奠定基础。
Objective:To assess the current situation of rational use of proprietary Chinese medicines in emergency department.Methods:Subject search was carried out by using“rational drug use”OR“prescription analysis”OR“prescription review”AND“Chinese patent medicine”OR“traditional Chinese medicine injection”OR“injection”AND“emergency”in CNKI database,and all literatures from the establishment of the database to August 1,2022 were sorted by literature source,publication year,author and institution.The literature was classified by region,age distribution of the study population,and irrational drug use,and bibliometrics was used to evaluate the rational use of proprietary Chinese medicines in emergency department.Results:A total of 121 literature published in 65 journals were included.The research on the rational use of proprietary Chinese medicines in emergency department was on the rise,and researchers in East China were relatively more concerned about the rational use of proprietary Chinese medicines in emergency department.The total number of prescriptions in the included literature was 1160273,including 15815 irrational prescriptions.Among them,non-conformant prescriptions,inappropriate prescriptions and extraordinary prescriptions accounted for 21.16%,57.53%and 10.79%,respectively.The total number of emergency prescriptions of proprietary Chinese medicines for children(or infants)was 32179,and the number of unreasonable prescriptions was 2211.Among them,non-conformant prescriptions,inappropriate prescriptions and extraordinary prescriptions accounted for 16.46%,30.48%and 50.57%,respectively.The irrational drug use in children mainly involved heat-clearing and expectorant Chinese patent medicines,and the irrational drug use was mainly off-label.The elderly in the emergency department mainly used proprietary Chinese medicines for promoting blood circulation and removing blood stasis,and the irrational drug use mainly involved repeated administration and inappropriate combination medication.The
作者
马杭琨
栗蕊
李辰飞
高洪阳
高蕊
李庆娜
MA Hang-kun;LI Rui;LI Chen-fei;GAO Hong-yang;GAO Rui;LI Qing-na(Xiyuan Hospital,China Academy of Chinese Medical Sciences,Beijing 100091,China;The First Affiliated Hospital of Henan University of Chinese Medicine,Zhengzhou 477150,China;Institute of Clinical Pharmacology,Xiyuan Hospital,China Academy of Chinese Medical Sciences,Key Laboratory of Clinical Research and Evaluation of Traditional Chinese Medicine,State Drug Administration,National Clinical Research Center for Cardiovascular Diseases of Traditional Chinese Medicine,Beijing 100091,China)
出处
《中国新药杂志》
CAS
CSCD
北大核心
2023年第4期357-363,共7页
Chinese Journal of New Drugs
基金
国家“重大新药创制”科技重大专项资助项目(2017ZX09304003)
中国中医科学院科技创新工程项目(CI2021A04701)。
关键词
中成药
急诊科
合理用药
文献计量学
proprietary Chinese medicines
emergency department
rational use of medication
bibliometrics
