摘要
目的了解城市社区老年人群代谢综合征(MS)及其组分与校正的QT间期(QTc间期)延长的相关性。方法采用典型抽样流行病学调查方法对2011年9-11月1046例宁夏回族自治区5城市社区老年人群进行问卷调查、体格检查,其中1028例完成生化指标、心电图检查等,既往存在冠心病、心律失常等心血管疾病者233例,最终纳入795例。以2004年中华医学会糖尿病学分会提出的MS诊断标准及QTc间期延长(QTc>440 ms)为依据分为MS组、非MS组和正常组。分析MS及其不同组分,以及吸烟、饮酒与QTc间期延长的相关性。结果MS组患者QTc间期明显长于非MS组,血压升高组、血糖升高组,以及吸烟组、饮酒组患者QTc间期明显长于正常组,差异均有统计学意义(P<0.05);超重/肥胖组、血脂异常组患者QTc间期长于正常组,但差异无统计学意义(P>0.05)。QTc间期延长与MS、空腹血糖、收缩压均呈正相关(P<0.05);空腹血糖升高、收缩压升高是QTc间期延长的危险因素(P<0.05)。结论MS与QTc间期延长显著相关,空腹血糖、血压升高可能是QTc延长的危险因素,应关注MS患者空腹血糖、血压情况,预防心律失常事件的发生。
Objective To investigate the correlation between metabolic syndrome(MS)and its components and corrected QTc interval prolongation in the elderly population in urban communities.Methods Using the typical sampling epidemiological survey method from September to November 2011,1046 elderly people in urban communities were investigated by questionnaire,1028 completed physical examination,biochemical indices and electrocardiogram examination.A total of 233 cases with incomplete data and previous cardiovascular diseases such as coronary heart disease and arrhythmia were excluded,and 795 cases were finally included in this study.According to the MS diagnostic criteria proposed by Chinese diabetes society in 2004 and QTc>440 ms as the basis of QTc interval prolongation,the subjects were divided into the MS group,the non-MS group and the normal group.The correlation between MS and its different components,smoking and drinking and QTc interval prolongation was analyzed.Results The QTc interval prolongation in the MS group was significantly longer than that in the non-MS group,and the blood pressure and blood sugar increased.The QTc interval in the smoking and drinking group was significantly longer than that in the normal group,with statistically significant difference(P<0.05).The QTc interval prolongation in the overweight/obesity and dyslipidemia patients was longer than that in the normal group,but the difference was not statistically significant(P>0.05).The prolongation of QTc interval was positively correlated with MS,fasting blood glucose(FPG)and systolic blood pressure(P<0.05).Abnormal increase of FPG and systolic blood pressure were risk factors for the prolongation of QTc interval(P<0.05).Conclusion MS is significantly correlated with QTc interval prolongation,and the increase of FPG and blood pressure may be the risk factors of QTc interval prolongation.More attention should be paid to the observation of FPG and blood pressure in MS patients to prevent serious arrhythmia.
作者
马万瑞
何珊
齐国雪
王志忠
MA Wanrui;HE Shan;QI Guoxue;WANG Zhizhong(Depart of Geriatrics,The First Dongguan Affiliated Hospital,Guangdong Medical University,Dongguan,Guangdong 523710,China;The second Clinical Medical College,Guangdong Medical University,Dongguan,Guangdong 523808,China;Graduate school,Ningxia Medical University,Yinchuan,Ningxia 750004,China;Center of Cardiac Diagnosis and Treatment,The First People′s Hospital of Yinchuan,Yinchuan,Ningxia 750004,China;Department of Epidemiology and Health Statistics,School of Public Health at Guangdong Medical University,Dongguan,Guangdong 523808,China)
出处
《现代医药卫生》
2023年第7期1081-1084,共4页
Journal of Modern Medicine & Health
基金
国家自然科学基金项目(81860599)
广东医科大学附属东莞第一院高层次人才科研资助计划基金项目(GCC20230033)。
关键词
代谢综合征
高血压
高血糖
QTC间期
Metabolic syndrome
Hypertension
Hyperglycemia
QTc interval
