摘要
一枝蒿庚素是一种C20一二萜生物碱,为川乌等乌头属药用植物的主要有效化学成分之一。近年来,随着一枝蒿庚素药用价值的不断开发,其提纯工艺与含量测定技术因可直接影响药物质量与临床药用安全受到了研究人员们的广泛关注。目前,一枝蒿庚素的提纯方法主要有酸水提取法、氨碱化乙醚冷浸法、超声辅助提取法及纤维素酶提取法等;含量测定方法主要有紫外-分光光度法与高效液相色谱法等。本文对近年来一枝蒿庚素的提纯工艺及其含量测定技术的研究进行综述,以期为一枝蒿庚素的进一步开发与应用提供思路及依据。
Songorine is a C20-diterpenoid alkaloid,which is one of the main effective chemical components in the medicinal plants of Aconitum.In recent years,with the continuous development of the medicinal value of songorine,its purification process and content determination technology have been widely concerned by researchers because it can directly affect the product quality and clinical safety.At present,the main purification methods of songorine include acid water extraction,cold immersion of ammonia alkalization ether,ultrasonic assisted extraction and cellulose extraction.The content determination methods mainly include UV-spectrophotometry and high performance liquid chromatography.In this paper,the purification technology and content determination technology of songorine were reviewed in order to provide ideas and basis for further development and application of songorine.
作者
刘健
曹井龙
薛慧
李艳楠
侯文爽
金成浩
Liu Jian;Cao Jinglong;Xue Hui;Li Yannan;Hou Wenshuang;Jin Chenghao(College of Life Science&Technology,Heilongjiang Bayi Agricultural University,Heilongjiang,163319)
出处
《当代化工研究》
2023年第6期6-8,共3页
Modern Chemical Research
基金
2020年中央支持地方高校改革发展基金人才培养项目“玉米黄质提纯工艺优化及其抗肿瘤分子机制研究”(项目编号:2020GSP16)。
关键词
一枝蒿庚素
二萜生物碱
提纯工艺
含量测定
songorine
diterpenoid alkaloids
purification process
content determination
