摘要
龋病、外伤、医源性刺激等均可引起牙髓牙本质复合体损伤,保存活髓、促进牙髓牙本质复合体的损伤修复对临床治疗至关重要。近年来研究发现,各类小分子化合物可通过细胞内关键信号通路和代谢途径等机制调控炎症,促进牙髓干细胞迁移、增殖、分化,促进血管、神经再生,从而促进牙髓牙本质复合体的损伤修复。该文旨在对近年来小分子化合物在促进牙髓牙本质复合体损伤修复中的应用研究作一综述。
Dental caries,trauma,and iatrogenic stimulation can cause damage to the dentin⁃pulp complex.Preserving the viable pulp and promoting damage repair of the dentin⁃pulp complex is of great clinical significance at present.In recent years,studies have found that various small molecular compounds can regulate inflammation,promote the migration,proliferation,and differentiation of dental pulp stem cells,promote blood vessel,nerve regeneration and other biological processes by regulating key intracellular signaling path⁃ways and metabolic pathways,and could thereby promote damage repair of the dentin⁃pulp complex.The objective of this paper is to re⁃view recent research on various small molecular compounds used in promoting the repair of dentin⁃pulp complex.
作者
邵皎皎
张旗
SHAO Jiaojiao;ZHANG Qi(Department of Dentistry and Endodontics,Stomatological Hospital and Dental School of Tongji University,Shanghai Engineering Research Center of Tooth Restoration and Regeneration,Shanghai 200072,China)
出处
《口腔医学》
CAS
2023年第3期256-260,288,共6页
Stomatology
基金
国家自然科学基金(82170945,81870760)
临床“五新”创新研发项目(SHDC2020CR3058B)。
