摘要
目的探讨瑞马唑仑对老年髋关节置换术后苏醒效果及认知功能的影响。方法本研究对象为我院2019年10月~2021年10月100例老年髋关节置换术患者,数字表法随机分为两组。对照组采用咪达唑仑、舒芬太尼、罗库溴铵进行麻醉诱导,观察组采用瑞马唑仑、舒芬太尼、罗库溴铵进行麻醉诱导。比较两组患者术中情况、术后睁眼、拔管时间等苏醒情况以及术后呼吸抑制、躁动等并发症发生率,评估术前、术后12h、1d、3d时的简易精神状态评价量表(MMSE)评分。结果两组手术时间、出血量差异无统计学意义(P>0.05),观察组术后睁眼时间、拔管时间均显著低于对照组(P<0.05);观察组术后认知功能障碍、躁动等并发症发生率显著低于对照组(P<0.05),呼吸抑制、头晕头痛、恶心呕吐发生率差异无统计学意义(P>0.05);两组术后12h、1dMMSE评分低于术前,但观察组显著高于对照组(P<0.05),两组术后3d MMSE评分差异无统计学意义(P>0.05)。结论瑞马唑仑用于老年髋关节置换术麻醉诱导相较于常规药物咪达唑仑能够提升术后苏醒质量,降低躁动、认知功能障碍等并发症发生率,降低术后早期认知功能障碍。
Objective To investigate the effect of remazolam on the recovery effect and cognitive function of elderly patients after hip replacement.Methods A total of 100 elderly patients with hip replacement in our hospital from October 2019 to October 2021 were the subjects of this study,and randomly divided into two groups by digital table method.The control group was treated with midazolam,sufentanil,and rocuronium bromide for induction of anesthesia,while the observation group was treated with remazolam,sufentanil,and rocuronium bromide for anesthesia induction.The intraoperative conditions,postoperative recovery time such as eye opening and extubation time,and postoperative respiratory depression,agitation and other complications were compared between the two groups.The Mini-Mental State Evaluation Scale(MMSE)scores were evaluated before surgery and at 12h,1d,and 3d after surgery.Results There was no significant difference in operation time and blood loss between the two groups(P>0.05).The postoperative eye-opening time and extubation time of the observation group were significantly lower than those of the control group(P<0.05).The incidence of postoperative complications such as cognitive dysfunction and restlessness in the observation group was significantly lower than that in the control group(P<0.05).There was no significant difference in the incidence rates of respiratory depression,dizziness,headache,nausea and vomiting(P>0.05).The MMSE scores at 12h and 1d after operation in the two groups were lower than those before operation,but the observation group was significantly higher than the control group(P<0.05).There was no significant difference in MMSE scores between the two groups at 3 days after operation(P>0.05).Conclusion Compared with midazolam,remazolam can improve the quality of postoperative recovery,reduce the incidence of complications such as restlessness and cognitive dysfunction,and reduce early postoperative cognitive dysfunction.
作者
史牛华
SHI Niuhua(Zhengzhou Hospital of Traditional Chinese Medicine,Zhengzhou 450007,China)
出处
《国际精神病学杂志》
2023年第1期132-134,共3页
Journal Of International Psychiatry
