摘要
目的 分析脑出血合并肺部感染患者应用药学干预对于改善体内炎症因子水平的有效性。方法 80例脑出血并发肺部感染患者,按照随机双盲法分为对照组与观察组,每组40例。对照组患者给予常规治疗干预,观察组患者在对照组基础上给予药学干预。比较两组患者干预前后炎症因子、舒张压、收缩压、血氧饱和度、神经功能及满意度、并发症发生率。结果 干预后,观察组患者超敏C反应蛋白、肿瘤坏死因子-α、白细胞介素-6水平分别为(8.28±0.38)mg/L、(66.76±8.78)pg/ml、(6.26±0.42)ng/L,均低于对照组的(13.51±1.26)mg/L、(106.36±8.98)pg/ml、(10.45±1.31)ng/L,差异具有统计学意义(P<0.05)。干预后,观察组患者收缩压(112.72±11.21)mm Hg(1 mm Hg=0.133 kPa)、舒张压(80.37±5.62)mm Hg低于对照组的(123.55±12.32)、(86.76±6.11)mm Hg,血氧饱和度(97.87±5.15)%高于对照组的(92.62±6.26)%,差异具有统计学意义(P<0.05)。观察组患者的总满意率为97.50%,高于对照组的77.50%,差异具有统计学意义(P<0.05)。观察组患者并发症发生率为5.00%,低于对照组的27.50%,差异具有统计学意义(P<0.05)。干预后,观察组患者美国国立卫生研究院卒中量表(NIHSS)评分(4.76±1.26)分低于对照组的(6.78±1.76)分,差异具有统计学意义(P<0.05)。结论 脑出血合并肺部感染患者行药学干预可以更好地改善患者体内的炎症因子水平,值得在临床中予以使用与推广。
Objective To analyze the effectiveness of pharmaceutical intervention on the level of inflammatory factors in patients with cerebral hemorrhage and pulmonary infection.Methods A total of 80 patients with cerebral hemorrhage and pulmonary infection were randomly divided into control group and observation group,with 40 cases in each group.The control group received conventional treatment and intervention,and the observation group received pharmaceutical intervention on the basis of the control group.Both groups were compared in terms of inflammatory factors,diastolic blood pressure,systolic blood pressure,oxygen saturation,and nerve function before and after the intervention,satisfaction and complication rate.Results After the intervention,the levels of high-sensitivity C-reactive protein,tumor necrosis factor-αand interleukin-6 in the observation group were(8.28±0.38)mg/L,(66.76±8.78)pg/ml and(6.26±0.42)ng/L,which were lower than(13.51±1.26)mg/L,(106.36±8.98)pg/ml and(10.45±1.31)ng/L in the control group,and the differences were statistically significant(P<0.05).After the intervention,the systolic blood pressure(112.72±11.21)mm Hg(1 mm Hg=0.133 kPa)and diastolic blood pressure(80.37±5.62)mm Hg in the observation group were lower than(123.55±12.32)and(86.76±6.11)mm Hg in the control group;the oxygen saturation(97.87±5.15)%in the observation group was higher than(92.62±6.26)%in the control group;the differences were statistically significant(P<0.05).The overall satisfaction rate in the observation group was 97.50%,which was higher than 77.50%in the control group,and the difference was statistically significant(P<0.05).The complication rate in the observation group was 5.00%,which was lower than 27.50%in the control group,and the difference was statistically significant(P<0.05).After the intervention,the National Institutes of Health Stroke Scale(NIHSS)score was(4.76±1.26)points in the observation group,which was lower than(6.78±1.76)points in the control group,and the difference was statistically sign
作者
康方方
曹兴念
KANG Fang-fang;CAO Xing-nian(Department of Neurology,Weihai Maternal and Child Health Hospital,Weihai 264200,China)
出处
《中国实用医药》
2023年第6期152-155,共4页
China Practical Medicine
关键词
脑出血
肺部感染
炎症因子
药学干预
满意度
Cerebral hemorrhage
Pulmonary infection
Inflammatory factors
Pharmaceutical intervention
Satisfaction
